CYLD

CYLD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IXD, 1WHL, 1WHM, 2VHF
Dynodwyr
Cyfenwau	CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD lysine 63 deubiquitinase
Dynodwyr allanol	OMIM: 605018 HomoloGene: 9069 GeneCards: CYLD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • zinc ion binding • metal ion binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • thiol-dependent deubiquitinase • proline-rich region binding • hydrolase activity • protein kinase binding • Lys63-specific deubiquitinase activity • Lys48-specific deubiquitinase activity • structural constituent of ribosome Cydrannau o'r gell • cytoplasm • cytosol • centrosome • cell projection • bilen • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • spindle • microtubule organizing center • midbody • perinuclear region of cytoplasm • cytoplasmic microtubule • Cytosgerbwd • microtubule • ciliary basal body • ciliary tip Prosesau biolegol • regulation of intrinsic apoptotic signaling pathway • ubiquitin-dependent protein catabolic process • regulation of microtubule cytoskeleton organization • Wnt signaling pathway • proteolysis • protein K63-linked deubiquitination • regulation of mitotic cell cycle • positive regulation of extrinsic apoptotic signaling pathway • cell cycle • negative regulation of type I interferon production • negative regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing signaling pathway • negative regulation of canonical Wnt signaling pathway • immune system process • regulation of tumor necrosis factor-mediated signaling pathway • protein deubiquitination • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • regulation of protein binding • innate immune response • regulation of B cell differentiation • negative regulation of T cell differentiation • positive regulation of T cell differentiation • homeostasis of number of cells • positive regulation of T cell receptor signaling pathway • GO:0060554, GO:0060555 necroptosis • protein K48-linked deubiquitination • ripoptosome assembly involved in necroptotic process • regulation of cilium assembly • positive regulation of protein localization • protein linear deubiquitination • cytoplasmic translation • negative regulation of NIK/NF-kappaB signaling • negative regulation of JNK cascade • negative regulation of p38MAPK cascade • regulation of inflammatory response • regulation of necroptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1540	n/a
Ensembl	ENSG00000083799	n/a
UniProt	Q9NQC7	n/a
RefSeq (mRNA)	NM_001042355 NM_001042412 NM_015247	n/a
RefSeq (protein)	NP_001035814 NP_001035877 NP_056062 NP_001365672 NP_001365673 NP_001365674 NP_001365675 NP_001365676 NP_001365677 NP_001365678 NP_001365679 NP_001365680 NP_001365681 NP_001365682 NP_001365683 NP_001365684 NP_001035814.1 NP_001035877.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYLD yw CYLD a elwir hefyd yn Ubiquitin carboxyl-terminal hydrolase CYLD (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYLD.

• EAC
• MFT
• SBS
• TEM
• BRSS
• CDMT
• MFT1
• CYLD1
• CYLDI
• USPL2

Llyfryddiaeth

• "Dishevelled proteins and CYLD reciprocally regulate each other in CML cell lines. ". Mol Biol Rep. 2017. PMID 28840581.
• "The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. ". Cell Biochem Funct. 2016. PMID 27570065.
• "The CYLD p.R758X worldwide recurrent nonsense mutation detected in patients with multiple familial trichoepithelioma type 1, Brooke-Spiegler syndrome and familial cylindromatosis represents a mutational hotspot in the gene. ". BMC Genet. 2016. PMID 26861065.
• "UV Irradiation Triggers Cylindromatosis Translocation, Modification, and Degradation in a Proteasome-Independent Manner. ". DNA Cell Biol. 2016. PMID 26717101.
• "Inherited cylindromas: lessons from a rare tumour.". Lancet Oncol. 2015. PMID 26370355.