CXCR4

CXCR4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4RWS, 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9, 2N55
Dynodwyr
Cyfenwau	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, C-X-C motif chemokine receptor 4, WHIMS1
Dynodwyr allanol	OMIM: 162643 HomoloGene: 20739 GeneCards: CXCR4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0019974 cytokine binding • coreceptor activity • virus receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • chemokine receptor activity • myosin light chain binding • actin binding • ubiquitin protein ligase binding • G protein-coupled receptor activity • C-X-C chemokine receptor activity • ubiquitin binding • C-C chemokine binding • C-C chemokine receptor activity • chemokine binding • C-X-C motif chemokine 12 receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • endosome • bilen • cell surface • cell junction • cell leading edge • extracellular exosome • GO:0016023 cytoplasmic vesicle • early endosome • late endosome • lysosome • Cellbilen • external side of plasma membrane • GO:0009327 protein-containing complex • cnewyllyn cell Prosesau biolegol • myelin maintenance • positive regulation of oligodendrocyte differentiation • response to hypoxia • positive regulation of cytosolic calcium ion concentration • chemokine-mediated signaling pathway • response to virus • dendritic cell chemotaxis • cellular response to cytokine stimulus • chemotaxis • inflammatory response • calcium-mediated signaling • GO:0072468 signal transduction • GO:0097285 apoptotic process • GO:0022415 viral process • fusion of virus membrane with host plasma membrane • regulation of chemotaxis • G protein-coupled receptor signaling pathway • axon guidance • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • brain development • neurogenesis • CXCL12-activated CXCR4 signaling pathway • cell chemotaxis • positive regulation of cold-induced thermogenesis • regulation of cell adhesion • neuron migration • epithelial cell development • neuron recognition • response to activity • cell migration • telencephalon cell migration • positive regulation of cell migration • positive regulation of vascular wound healing • regulation of programmed cell death • response to morphine • endothelial cell differentiation • positive regulation of neurogenesis • regulation of viral process • positive regulation of chemotaxis • detection of temperature stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception of pain • regulation of calcium ion transport • cardiac muscle contraction • endothelial tube morphogenesis • positive regulation of dendrite extension • positive regulation of mesenchymal stem cell migration • response to ultrasound Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7852	n/a
Ensembl	ENSG00000121966	n/a
UniProt	P61073	n/a
RefSeq (mRNA)	NM_003467 NM_001008540 NM_001348056 NM_001348059 NM_001348060	n/a
RefSeq (protein)	NP_001008540 NP_003458 NP_001334985 NP_001334988 NP_001334989	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCR4 yw CXCR4 a elwir hefyd yn C-X-C motif chemokine receptor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCR4.

• FB22
• HM89
• LAP3
• LCR1
• NPYR
• WHIM
• CD184
• LAP-3
• LESTR
• NPY3R
• NPYRL
• WHIMS
• HSY3RR
• NPYY3R
• D2S201E

Llyfryddiaeth

• "Emergence of CXCR4-tropic HIV-1 variants followed by rapid disease progression in hemophiliac slow progressors. ". PLoS One. 2017. PMID 28472121.
• "Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. ". Circulation. 2017. PMID 28450349.
• "CXCR4 (CD184) expression on stem cell harvest and CD34+ cells post-transplant. ". Hematol Oncol Stem Cell Ther. 2017. PMID 28282510.
• "Chemotherapy induces adaptive drug resistance and metastatic potentials via phenotypic CXCR4-expressing cell state transition in ovarian cancer. ". PLoS One. 2017. PMID 28196146.
• "Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions.". Biochem Biophys Res Commun. 2017. PMID 28126341.