CXCL12

CXCL12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A15, 1QG7, 1SDF, 1VMC, 2J7Z, 2K01, 2K03, 2K04, 2K05, 2KEC, 2KED, 2KEE, 2KOL, 2NWG, 2SDF, 3GV3, 3HP3, 4LMQ, 4UAI, 2N55
Dynodwyr
Cyfenwau	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12
Dynodwyr allanol	OMIM: 600835 HomoloGene: 128606 GeneCards: CXCL12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • chemokine receptor binding • cytokine activity • chemokine activity • CXCR chemokine receptor binding • chemoattractant activity • growth factor activity • signaling receptor binding • integrin binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • Cellbilen • extracellular region • extracellular exosome • external side of plasma membrane • extracellular space • cytoplasm • cnewyllyn cell • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of leukocyte tethering or rolling • G protein-coupled receptor signaling pathway • regulation of calcium ion transport • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of cell migration • chemokine-mediated signaling pathway • adult locomotory behavior • response to mechanical stimulus • response to peptide hormone • positive regulation of monocyte chemotaxis • cellular calcium ion homeostasis • response to virus • neuron migration • response to heat • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of axon extension involved in axon guidance • blood circulation • telencephalon cell migration • chemotaxis • regulation of actin polymerization or depolymerization • positive regulation of calcium ion import • brain development • cell adhesion • positive regulation of dopamine secretion • animal organ regeneration • positive regulation of neuron differentiation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • cell chemotaxis • negative regulation of leukocyte apoptotic process • response to radiation • positive regulation of T cell migration • positive regulation of cell adhesion • GO:0072468 signal transduction • positive chemotaxis • induction of positive chemotaxis • defense response • response to ultrasound • antimicrobial humoral immune response mediated by antimicrobial peptide • T cell chemotaxis • detection of temperature stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception of pain • regulation of signaling receptor activity • axon guidance • GO:0022415 viral process • integrin activation • chemokine (C-X-C motif) ligand 12 signaling pathway • cellular response to chemokine • negative regulation of dendritic cell apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6387	n/a
Ensembl	ENSG00000107562	n/a
UniProt	P48061	n/a
RefSeq (mRNA)	NM_199168 NM_000609 NM_001033886 NM_001178134 NM_001277990	n/a
RefSeq (protein)	NP_000600 NP_001029058 NP_001171605 NP_001264919 NP_954637	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCL12 yw CXCL12 a elwir hefyd yn C-X-C motif chemokine ligand 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCL12.

• IRH
• PBSF
• SDF1
• TLSF
• TPAR1
• SCYB12

Llyfryddiaeth

• "Angiogenesis mediators in women with idiopathic heavy menstrual bleeding. ". Int J Gynaecol Obstet. 2017. PMID 28099683.
• "Polymorphism-801G/A in the 3'-untranslated region of CXCL12 is not associated with preeclampsia in Chinese Han population. ". Clin Exp Hypertens. 2017. PMID 28051881.
• "The SDF1 A/G Gene Variant: A Susceptibility Variant for Myocardial Infarction. ". Genet Test Mol Biomarkers. 2017. PMID 28650670.
• "Association between chemokine CXC ligand 12 gene polymorphism (rs1746048) and coronary heart disease: A MOOSE-compliant meta-analysis. ". Medicine (Baltimore). 2017. PMID 28614256.
• "Monomeric CXCL12 outperforms its dimeric and wild type variants in the promotion of human endothelial progenitor cells' function.". Biochem Biophys Res Commun. 2017. PMID 28487111.