CUL4B

CUL4B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DO7, 4A0C, 4A0L, 4A64
Dynodwyr
Cyfenwau	CUL4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B
Dynodwyr allanol	OMIM: 300304 HomoloGene: 2660 GeneCards: CUL4B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • damaged DNA binding • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding Cydrannau o'r gell • cullin-RING ubiquitin ligase complex • nucleoplasm • extracellular exosome • cnewyllyn cell • cytosol • Cul4B-RING E3 ubiquitin ligase complex • Cul4-RING E3 ubiquitin ligase complex • SCF ubiquitin ligase complex Prosesau biolegol • GO:1903364 positive regulation of protein catabolic process • nucleotide-excision repair, DNA damage recognition • ubiquitin-dependent protein catabolic process • histone H2A monoubiquitination • cellular response to DNA damage stimulus • positive regulation of G1/S transition of mitotic cell cycle • global genome nucleotide-excision repair • cell cycle • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • neuron projection development • UV-damage excision repair • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • GO:0100026 DNA repair • nucleotide-excision repair, preincision complex stabilization • post-translational protein modification • proteasomal protein catabolic process • protein ubiquitination • G1/S transition of mitotic cell cycle • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8450	n/a
Ensembl	ENSG00000158290	n/a
UniProt	Q13620	n/a
RefSeq (mRNA)	NM_001079872 NM_003588 NM_001330624 NM_001369145	n/a
RefSeq (protein)	NP_001073341 NP_001317553 NP_003579 NP_001356074	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CUL4B yw CUL4B a elwir hefyd yn Cullin 4B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq24.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CUL4B.

• SFM2
• MRXSC
• CUL-4B
• MRXHF2
• MRXS15

Llyfryddiaeth

• "CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells. ". Oncol Rep. 2014. PMID 25189186.
• "Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability. ". Am J Med Genet A. 2014. PMID 24898194.
• "Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells. ". Proteomics. 2017. PMID 28225217.
• "Knockdown of CUL4B Suppresses the Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. ". Oncol Res. 2016. PMID 27656838.
• "Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway.". Int J Clin Exp Pathol. 2015. PMID 26617747.