CUL1

CUL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LDJ, 1LDK, 1U6G, 3RTR, 3TDU, 3TDZ, 4F52, 4P5O
Dynodwyr
Cyfenwau	CUL1, cullin 1
Dynodwyr allanol	OMIM: 603134 HomoloGene: 2663 GeneCards: CUL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0050372 ubiquitin-protein transferase activity Cydrannau o'r gell • Parkin-FBXW7-Cul1 ubiquitin ligase complex • nucleoplasm • cytosol • cullin-RING ubiquitin ligase complex • SCF ubiquitin ligase complex Prosesau biolegol • intrinsic apoptotic signaling pathway • GO:0022415 viral process • G2/M transition of mitotic cell cycle • stress-activated MAPK cascade • ubiquitin-dependent protein catabolic process • protein monoubiquitination • cell population proliferation • negative regulation of cell population proliferation • animal organ morphogenesis • GO:0097285 apoptotic process • NIK/NF-kappaB signaling • protein ubiquitination • protein polyubiquitination • Wnt signaling pathway • SCF complex assembly • negative regulation of G2/M transition of mitotic cell cycle • cellular iron ion homeostasis • post-translational protein modification • G1/S transition of mitotic cell cycle • interleukin-1-mediated signaling pathway • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • regulation of mitotic cell cycle phase transition • proteasome-mediated ubiquitin-dependent protein catabolic process • stimulatory C-type lectin receptor signaling pathway • Fc-epsilon receptor signaling pathway • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8454	n/a
Ensembl	ENSG00000055130	n/a
UniProt	Q13616	n/a
RefSeq (mRNA)	NM_003592	n/a
RefSeq (protein)	NP_003583	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CUL1 yw CUL1 a elwir hefyd yn Cullin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q36.1.

Llyfryddiaeth

• "Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer. ". Int J Clin Exp Pathol. 2015. PMID 25973042.
• "Cullin1 is a novel prognostic marker and regulates the cell proliferation and metastasis in colorectal cancer. ". J Cancer Res Clin Oncol. 2015. PMID 25652886.
• "Increasing the Unneddylated Cullin1 Portion Rescues the csnPhenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly. ". Mol Cell Biol. 2017. PMID 28923850.
• "The expression of Cullin1 is increased in renal cell carcinoma and promotes cancer cell proliferation, migration, and invasion. ". Tumour Biol. 2016. PMID 27449035.
• "Cullin1 is up-regulated and associated with poor patients' survival in hepatocellular carcinoma.". Int J Clin Exp Pathol. 2015. PMID 26097587.