CTSD

CTSD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LYA, 1LYB, 1LYW, 4OBZ, 4OC6, 4OD9
Dynodwyr
Cyfenwau	CTSD, CLN10, CPSD, HEL-S-130P, cathepsin D
Dynodwyr allanol	OMIM: 116840 HomoloGene: 55616 GeneCards: CTSD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • hydrolase activity • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase activity • cysteine-type endopeptidase activity • aspartic-type endopeptidase activity • aspartic-type peptidase activity Cydrannau o'r gell • lysosomal lumen • extracellular exosome • membrane raft • GO:0005578 extracellular matrix • lysosome • melanosome • extracellular space • specific granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen • extracellular region • collagen-containing extracellular matrix • lysosomal membrane • endosome membrane Prosesau biolegol • GO:0044257 protein catabolic process • autophagy • collagen catabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • proteolysis • neutrophil degranulation • lipoprotein catabolic process • positive regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of establishment of protein localization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1509	n/a
Ensembl	ENSG00000117984	n/a
UniProt	P07339	n/a
RefSeq (mRNA)	NM_001909	n/a
RefSeq (protein)	NP_001900	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSD yw CTSD a elwir hefyd yn Cathepsin D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSD.

• CPSD
• CLN10
• HEL-S-130P

Llyfryddiaeth

• "Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. ". Int J Mol Sci. 2017. PMID 28218663.
• "Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL. ". Tumour Biol. 2016. PMID 26867770.
• "Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. ". Cell Death Dis. 2015. PMID 26448324.
• "Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies. ". Oncotarget. 2015. PMID 26203049.
• "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria.". Cell Death Dis. 2015. PMID 26086961.