CTNNB1 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1G3J , 1JDH , 1JPW , 1LUJ , 1P22 , 1QZ7 , 1T08 , 1TH1 , 2GL7 , 2Z6H , 3DIW , 3SL9 , 3SLA , 3TX7 , 4DJS , 3FQN , 3FQR
Dynodwyr Cyfenwau CTNNB1 , CTNNB, MRD19, armadillo, catenin beta 1, EVR7, NEDSDVDynodwyr allanol OMIM: 116806 HomoloGene: 1434 GeneCards: CTNNB1 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • SMAD binding • chromatin binding • signal transducer activity • double-stranded DNA binding • protein C-terminus binding • protein kinase binding • kinase binding • androgen receptor binding • transmembrane transporter binding • estrogen receptor binding • I-SMAD binding • protein phosphatase binding • transcription factor binding • GO:0001105 transcription coactivator activity • alpha-catenin binding • enzyme binding • RNA polymerase II core promoter sequence-specific DNA binding • protein heterodimerization activity • cadherin binding • disordered domain specific binding Cydrannau o'r gell • adherens junction • beta-catenin destruction complex • protein-DNA complex • lamellipodium • beta-catenin-TCF complex • beta-catenin-TCF7L2 complex • centrosome • Z disc • bicellular tight junction • transcription regulator complex • lateral plasma membrane • cytoplasm • cell cortex • apical part of cell • spindle pole • Scrib-APC-beta-catenin complex • catenin-TCF7L2 complex • flotillin complex • intercalated disc • cnewyllyn cell • cell-cell junction • bilen • Wnt signalosome • basolateral plasma membrane • Cellbilen • Cytosgerbwd • extracellular exosome • nucleoplasm • microtubule organizing center • cyrion cell • apical junction complex • cell projection membrane • focal adhesion • microvillus membrane • fascia adherens • cytosol • cell junction • perinuclear region of cytoplasm • catenin complex • synapse • intracellular anatomical structure • GO:0009327 protein-containing complex • presynaptic membrane • cell projection • postsynaptic membrane • Schaffer collateral - CA1 synapse • presynaptic active zone cytoplasmic component • postsynaptic density, intracellular component Prosesau biolegol • embryonic brain development • negative regulation of cell population proliferation • renal vesicle formation • positive regulation of MAPK cascade • proximal/distal pattern formation • positive regulation of neuroblast proliferation • chemical synaptic transmission • central nervous system vasculogenesis • renal inner medulla development • transcription, DNA-templated • positive regulation of neuron apoptotic process • canonical Wnt signaling pathway • embryonic foregut morphogenesis • endoderm formation • endodermal cell fate commitment • synapse organization • trachea formation • GO:0006928 cellular process • positive regulation of telomere maintenance via telomerase • neural plate development • negative regulation of protein sumoylation • lung cell differentiation • vasculogenesis • lung induction • hemopoiesis • kidney development • GO:1901313 positive regulation of gene expression • adherens junction organization • renal outer medulla development • thymus development • regulation of myelination • positive regulation of cell population proliferation • epithelial tube branching involved in lung morphogenesis • bone resorption • epithelial cell differentiation involved in prostate gland development • regulation of euchromatin binding • hair follicle morphogenesis • hair follicle placode formation • neuron migration • negative regulation of chondrocyte differentiation • fungiform papilla formation • positive regulation of type I interferon production • negative regulation of mitotic cell cycle, embryonic • ectoderm development • trachea morphogenesis • T cell differentiation in thymus • pancreas development • cranial ganglion development • regulation of apoptotic process • lung development • positive regulation of skeletal muscle tissue development • synaptic vesicle transport • positive regulation of telomerase activity • morphogenesis of embryonic epithelium • renal system development • oocyte development • hair cycle process • embryonic axis specification • embryonic forelimb morphogenesis • anterior/posterior axis specification • positive regulation of endothelial cell differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • animal organ development • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • dorsal/ventral axis specification • positive regulation of muscle cell differentiation • positive regulation of apoptotic process • regulation of protein localization to cell surface • androgen receptor signaling pathway • nervous system development • forebrain development • hair cell differentiation • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of epithelial cell differentiation • positive regulation of histone H3-K4 methylation • embryonic digit morphogenesis • endothelial tube morphogenesis • osteoclast differentiation • GO:0009373 regulation of transcription, DNA-templated • regulation of osteoclast differentiation • neuron differentiation • epithelial to mesenchymal transition • cell fate specification • odontogenesis of dentin-containing tooth • midbrain development • positive regulation of mesenchymal cell proliferation • positive regulation of heparan sulfate proteoglycan biosynthetic process • smooth muscle cell differentiation • glial cell fate determination • cell fate determination • positive regulation of determination of dorsal identity • regulation of T cell proliferation • gastrulation with mouth forming second • negative regulation of apoptotic signaling pathway • oviduct development • cellular response to growth factor stimulus • male genitalia development • negative regulation of gene expression • nephron tubule formation • regulation of osteoblast differentiation • regulation of angiogenesis • cell morphogenesis involved in differentiation • cell-matrix adhesion • dorsal root ganglion development • regulation of cell population proliferation • embryonic skeletal limb joint morphogenesis • heart development • T cell differentiation • dorsal/ventral pattern formation • layer formation in cerebral cortex • canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition • positive regulation of osteoblast differentiation • negative regulation of osteoclast differentiation • regulation of core promoter binding • genitalia morphogenesis • negative regulation of neuron death • cell maturation • cell population proliferation • branching involved in ureteric bud morphogenesis • cell differentiation • protein localization to cell surface • embryonic hindlimb morphogenesis • negative regulation of oligodendrocyte differentiation • metanephros morphogenesis • regulation of centriole-centriole cohesion • limb development • positive regulation of epithelial cell proliferation involved in prostate gland development • regulation of secondary heart field cardioblast proliferation • regulation of fibroblast proliferation • regulation of smooth muscle cell proliferation • skin development • skeletal system development • hindbrain development • regulation of calcium ion import • mesenchymal cell proliferation involved in lung development • regulation of nephron tubule epithelial cell differentiation • cellular response to indole-3-methanol • canonical Wnt signaling pathway involved in negative regulation of apoptotic process • regulation of gene expression • regulation of cell differentiation • stem cell population maintenance • regulation of neurogenesis • in utero embryonic development • lung-associated mesenchyme development • negative regulation of cell differentiation • positive regulation of I-kappaB kinase/NF-kappaB signaling • vasculature development • sympathetic ganglion development • positive regulation of epithelial cell differentiation • positive regulation of branching involved in lung morphogenesis • lens morphogenesis in camera-type eye • positive regulation of epithelial to mesenchymal transition • positive regulation of fibroblast growth factor receptor signaling pathway • embryonic heart tube development • regulation of centromeric sister chromatid cohesion • positive regulation of DNA-templated transcription, initiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • branching involved in blood vessel morphogenesis • positive regulation of DNA-binding transcription factor activity • cell adhesion • GO:0045996 negative regulation of transcription, DNA-templated • adherens junction assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Wnt signaling pathway, calcium modulating pathway • beta-catenin-TCF complex assembly • beta-catenin destruction complex disassembly • cranial skeletal system development • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • response to estradiol • midbrain dopaminergic neuron differentiation • entry of bacterium into host cell • negative regulation of oxidative stress-induced neuron death • positive regulation of core promoter binding • GO:0022415 viral process • negative regulation of angiogenesis • negative regulation of epithelial cell differentiation • negative regulation of apoptotic process • positive regulation of molecular function • positive regulation of epithelial cell proliferation • negative regulation of neurogenesis • regulation of timing of anagen • regulation of canonical Wnt signaling pathway • synaptic vesicle clustering • cell-cell adhesion • neuron projection extension • positive regulation of neural precursor cell proliferation • protein polyubiquitination • tissue homeostasis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn CTNNB1 yw CTNNB1 a elwir hefyd yn Catenin beta 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p22.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTNNB1.
EVR7
CTNNB
MRD19
armadillo
"Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82. ". J Invest Dermatol . 2017. PMID 28807667 .
"Curcumin inhibits bladder cancer progression via regulation of β-catenin expression. ". Tumour Biol . 2017. PMID 28705118 .
"Defects in the Cell Signaling Mediator β-Catenin Cause the Retinal Vascular Condition FEVR. ". Am J Hum Genet . 2017. PMID 28575650 .
"CTNNB1Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation. ". Anticancer Res . 2017. PMID 28551672 .
"Significance of β-catenin expression for the incidence of pathological fractures in giant cell tumors of bone. ". Pol J Pathol . 2016. PMID 28547961 .