CTNNA1

CTNNA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H6G, 4EHP, 4IGG
Dynodwyr
Cyfenwau	CTNNA1, CAP102, Catenin, MDPT2, catenin alpha 1
Dynodwyr allanol	OMIM: 116805 HomoloGene: 1433 GeneCards: CTNNA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • gamma-catenin binding • actin filament binding • beta-catenin binding • GO:0001948, GO:0016582 protein binding • vinculin binding • structural molecule activity • protein heterodimerization activity • RNA binding • cadherin binding • identical protein binding Cydrannau o'r gell • acrosomal vesicle • Cytosgerbwd • intracellular membrane-bounded organelle • intercalated disc • actin cytoskeleton • adherens junction • catenin complex • cytosol • bilen • Cellbilen • cytoplasm • cell-cell junction • cell junction • lamellipodium • Golgi apparatus • focal adhesion • zonula adherens • flotillin complex Prosesau biolegol • positive regulation of smoothened signaling pathway • actin filament organization • response to estrogen • regulation of cell population proliferation • GO:1904578 response to organic cyclic compound • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of neuroblast proliferation • establishment or maintenance of cell polarity • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • gap junction assembly • negative regulation of cell motility • negative regulation of integrin-mediated signaling pathway • apical junction assembly • cell adhesion • GO:0010260 heneiddio • male gonad development • protein heterooligomerization • adherens junction organization • positive regulation of muscle cell differentiation • ovarian follicle development • odontogenesis of dentin-containing tooth • cellular response to indole-3-methanol • negative regulation of apoptotic process • axon regeneration • epithelial cell-cell adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1495	n/a
Ensembl	ENSG00000044115	n/a
UniProt	P35221	n/a
RefSeq (mRNA)	NM_001290307 NM_001290309 NM_001290310 NM_001290312 NM_001903 NM_001323982 NM_001323983 NM_001323984 NM_001323985 NM_001323986 NM_001323987 NM_001323988 NM_001323989 NM_001323990 NM_001323991 NM_001323992 NM_001323993 NM_001323994 NM_001323995 NM_001323996 NM_001323997 NM_001323998 NM_001323999 NM_001324000 NM_001324001 NM_001324002 NM_001324003 NM_001324004 NM_001324005 NM_001324006 NM_001324007 NM_001324008 NM_001324009 NM_001324010 NM_001324011 NM_001324012 NM_001324013	n/a
RefSeq (protein)	NP_001277236 NP_001277238 NP_001277239 NP_001277241 NP_001310911 NP_001310912 NP_001310913 NP_001310914 NP_001310915 NP_001310916 NP_001310917 NP_001310918 NP_001310919 NP_001310920 NP_001310921 NP_001310922 NP_001310923 NP_001310924 NP_001310925 NP_001310926 NP_001310927 NP_001310928 NP_001310929 NP_001310930 NP_001310931 NP_001310932 NP_001310933 NP_001310934 NP_001310935 NP_001310936 NP_001310937 NP_001310938 NP_001310939 NP_001310940 NP_001310941 NP_001310942 NP_001894 NP_001277236.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTNNA1 yw CTNNA1 a elwir hefyd yn Catenin alpha-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTNNA1.

• MDPT2
• CAP102

Llyfryddiaeth

• "α-Catenin-mediated cadherin clustering couples cadherin and actin dynamics. ". J Cell Biol. 2015. PMID 26261181.
• "Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression. ". Sci Rep. 2015. PMID 26192076.
• "Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells. ". Apoptosis. 2015. PMID 25894537.
• "Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states. ". Curr Biol. 2015. PMID 25544608.
• "α-catenin. A tumor suppressor beyond adherens junctions.". Cell Cycle. 2014. PMID 25483184.