CTCF

CTCF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X6H, 2CT1
Dynodwyr
Cyfenwau	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
Dynodwyr allanol	OMIM: 604167 HomoloGene: 4786 GeneCards: CTCF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • chromatin insulator sequence binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding Cydrannau o'r gell • nucleoplasm • Cromosom • nucleolus • chromosome, centromeric region • condensed chromosome • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • regulation of centromeric sister chromatid cohesion • chromosome segregation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0045996 negative regulation of transcription, DNA-templated • protein localization to chromosome, centromeric region • negative regulation of cell population proliferation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • DNA methylation • regulation of gene expression by genetic imprinting • maintenance of DNA methylation • negative regulation of gene expression • regulation of histone methylation • regulation of histone acetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10664	n/a
Ensembl	ENSG00000102974	n/a
UniProt	P49711	n/a
RefSeq (mRNA)	NM_001191022 NM_006565 NM_001363916	n/a
RefSeq (protein)	NP_001177951 NP_006556 NP_001350845	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTCF yw CTCF a elwir hefyd yn CCCTC-binding factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTCF.

• MRD21

Llyfryddiaeth

• "CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions. ". Nucleic Acids Res. 2016. PMID 27638884.
• "Vitamin D-dependent chromatin association of CTCF in human monocytes. ". Biochim Biophys Acta. 2016. PMID 27569350.
• "Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. ". Mol Cell. 2017. PMID 28529057.
• "CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic. ". Oncogene. 2017. PMID 28319062.
• "Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.". Cell Rep. 2016. PMID 27974201.