CSTF2

CSTF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P1T, 2J8P
Dynodwyr
Cyfenwau	CSTF2, CstF-64, cleavage stimulation factor subunit 2
Dynodwyr allanol	OMIM: 300907 HomoloGene: 80171 GeneCards: CSTF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleic acid binding • GO:0001948, GO:0016582 protein binding • mRNA binding • RNA binding Cydrannau o'r gell • mRNA cleavage and polyadenylation specificity factor complex • cleavage body • nucleoplasm • cnewyllyn cell • nuclear body Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • mRNA 3'-end processing • pre-mRNA cleavage required for polyadenylation • tRNA splicing, via endonucleolytic cleavage and ligation • mRNA polyadenylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1478	n/a
Ensembl	ENSG00000101811	n/a
UniProt	P33240	n/a
RefSeq (mRNA)	NM_001306206 NM_001306209 NM_001325	n/a
RefSeq (protein)	NP_001293135 NP_001293138 NP_001316 NP_001293135.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSTF2 yw CSTF2 a elwir hefyd yn BetaCstF-64 variant 2 a Cleavage stimulation factor subunit 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSTF2.

• CstF-64

Llyfryddiaeth

• "Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. ". Nat Commun. 2014. PMID 25409906.
• "Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation. ". Proc Natl Acad Sci U S A. 2012. PMID 23112178.
• "Characterization of a cleavage stimulation factor, 3' pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer. ". Clin Cancer Res. 2011. PMID 21813631.
• "Characterization of Rous sarcoma virus polyadenylation site use in vitro. ". Virology. 2008. PMID 18272196.
• "Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein.". J Mol Biol. 2005. PMID 15769465.