CSF3R

CSF3R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D9Q
Dynodwyr
Cyfenwau	CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7
Dynodwyr allanol	OMIM: 138971 HomoloGene: 601 GeneCards: CSF3R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0016518 cytokine receptor activity • GO:0001948, GO:0016582 protein binding • granulocyte colony-stimulating factor binding • signaling receptor activity • interleukin-3 receptor activity • GO:0019974 cytokine binding • interleukin-3 binding Cydrannau o'r gell • integral component of membrane • extracellular region • integral component of plasma membrane • bilen • Cellbilen • external side of plasma membrane • receptor complex Prosesau biolegol • defense response • cell adhesion • regulation of myeloid cell differentiation • neutrophil chemotaxis • GO:0072468 signal transduction • amelogenesis • cytokine-mediated signaling pathway • cellular response to interleukin-3 • interleukin-3-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1441	n/a
Ensembl	ENSG00000119535	n/a
UniProt	Q99062	n/a
RefSeq (mRNA)	NM_000760 NM_156038 NM_156039 NM_172313	n/a
RefSeq (protein)	NP_000751 NP_724781 NP_758519	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSF3R yw CSF3R a elwir hefyd yn Colony stimulating factor 3 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p34.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSF3R.

• SCN7
• CD114
• GCSFR

Llyfryddiaeth

• "Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function. ". Cancer Res. 2017. PMID 28652245.
• "Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations. ". Leukemia. 2017. PMID 28439110.
• "Enhanced MAPK signaling is essential for CSF3R-induced leukemia. ". Leukemia. 2017. PMID 28031554.
• "Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia. ". Ann N Y Acad Sci. 2016. PMID 27270496.
• "Colony Stimulating Factor 3 Mutations and Myeloid Malignancies.". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016. PMID 26956865.