CSF2

CSF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1
Dynodwyr
Cyfenwau	CSF2, GMCSF, colony stimulating factor 2, CSF
Dynodwyr allanol	OMIM: 138960 HomoloGene: 600 GeneCards: CSF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • growth factor activity • granulocyte macrophage colony-stimulating factor receptor binding • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • cytokine activity Cydrannau o'r gell • extracellular region • intracellular membrane-bounded organelle • extracellular space Prosesau biolegol • negative regulation of cytolysis • positive regulation of macrophage derived foam cell differentiation • regulation of cell population proliferation • MAPK cascade • positive regulation of podosome assembly • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of interleukin-23 production • GO:1901313 positive regulation of gene expression • embryonic placenta development • epithelial fluid transport • regulation of gene expression • dendritic cell differentiation • myeloid dendritic cell differentiation • macrophage activation • cellular response to lipopolysaccharide • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • monocyte differentiation • response to fluid shear stress • response to silicon dioxide • neutrophil differentiation • peptidyl-tyrosine phosphorylation • regulation of circadian sleep/wake cycle, sleep • histamine secretion • positive regulation of tyrosine phosphorylation of STAT protein • cellular response to granulocyte macrophage colony-stimulating factor stimulus • regulation of myeloid cell differentiation • regulation of signaling receptor activity • GO:0045996 negative regulation of transcription, DNA-templated • cytokine-mediated signaling pathway • positive regulation of cell population proliferation • macrophage differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1437	n/a
Ensembl	ENSG00000164400	n/a
UniProt	P04141	n/a
RefSeq (mRNA)	NM_000758	n/a
RefSeq (protein)	NP_000749	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSF2 yw CSF2 a elwir hefyd yn Colony stimulating factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSF2.

• CSF
• GMCSF

Llyfryddiaeth

• "Honokiol possesses potential anti-inflammatory effects on rheumatoid arthritis and GM-CSF can be a target for its treatment. ". Int J Clin Exp Pathol. 2015. PMID 26339358.
• "T cell expression of granulocyte-macrophage colony-stimulating factor in juvenile arthritis is contingent upon Th17 plasticity. ". Arthritis Rheumatol. 2014. PMID 24692225.
• "Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor. ". BMC Res Notes. 2017. PMID 28376863.
• "Stimulatory versus suppressive effects of GM-CSF on tumor progression in multiple cancer types. ". Exp Mol Med. 2016. PMID 27364892.
• "Granulocyte macrophage colony-stimulating factor predicts postoperative recurrence of clear-cell renal cell carcinoma.". Oncotarget. 2016. PMID 27016418.