CRY1

CRY1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4CT0, 4K0R
Dynodwyr
Cyfenwau	CRY1, cryptochrome circadian clock 1, PHLL1, DSPD, cryptochrome circadian regulator 1
Dynodwyr allanol	OMIM: 601933 HomoloGene: 7042 GeneCards: CRY1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• deoxyribodipyrimidine photo-lyase activity; • DNA binding; • nucleotide binding; • phosphatase binding; • blue light photoreceptor activity; • transcription factor binding; • histone deacetylase binding; • DNA (6-4) photolyase activity; • core promoter sequence-specific DNA binding; • kinase binding; • GO:0001948, GO:0016582 protein binding; • photoreceptor activity; • double-stranded DNA binding; • protein kinase binding; • E-box binding; • lyase activity;
Cydrannau o'r gell	• cytoplasm; • mitocondria; • cnewyllyn cell;
Prosesau biolegol	• gluconeogenesis; • negative regulation of glucocorticoid receptor signaling pathway; • response to glucagon; • GO:0009373 regulation of transcription, DNA-templated; • glucose homeostasis; • response to stimulus; • proses rythmig; • negative regulation of circadian rhythm; • lipid storage; • GO:1901227 negative regulation of transcription by RNA polymerase II; • circadian regulation of gene expression; • transcription, DNA-templated; • response to insulin; • negative regulation of protein ubiquitination; • regulation of circadian rhythm; • regulation of DNA damage checkpoint; • DNA damage induced protein phosphorylation; • negative regulation of G protein-coupled receptor signaling pathway; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of glucocorticoid secretion; • entrainment of circadian clock by photoperiod; • blue light signaling pathway; • Rhythm circadaidd; • negative regulation of gluconeogenesis; • positive regulation of protein ubiquitination; • response to light stimulus; • response to activity;
	Sources:Amigo / QuickGO
Orthologau
	1407
	n/a
	ENSG00000008405
	n/a
	Q16526
	n/a
	NM_004075
	n/a
	NP_004066; NP_004066.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CRY1 yw CRY1 a elwir hefyd yn Cryptochrome circadian regulator 1 a Cryptochrome 1 (Photolyase-like), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CRY1.

DSPD
PHLL1

Llyfryddiaeth

"CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. ". Chronobiol Int. 2014. PMID 24548145.
"Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. ". PLoS One. 2013. PMID 23626715.
"Identification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function. ". J Biol Chem. 2012. PMID 22692217.
"Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia. ". PLoS One. 2012. PMID 22470559.
"Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia.". Haematologica. 2009. PMID 19181792.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CRY1 - Cronfa NCBI

[1]

[2]