CRY1

CRY1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4CT0, 4K0R
Dynodwyr
Cyfenwau	CRY1, cryptochrome circadian clock 1, PHLL1, DSPD, cryptochrome circadian regulator 1
Dynodwyr allanol	OMIM: 601933 HomoloGene: 7042 GeneCards: CRY1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • deoxyribodipyrimidine photo-lyase activity • DNA binding • nucleotide binding • phosphatase binding • blue light photoreceptor activity • transcription factor binding • histone deacetylase binding • DNA (6-4) photolyase activity • core promoter sequence-specific DNA binding • kinase binding • GO:0001948, GO:0016582 protein binding • photoreceptor activity • double-stranded DNA binding • protein kinase binding • E-box binding • lyase activity Cydrannau o'r gell • cytoplasm • mitocondria • cnewyllyn cell Prosesau biolegol • gluconeogenesis • negative regulation of glucocorticoid receptor signaling pathway • response to glucagon • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • response to stimulus • proses rythmig • negative regulation of circadian rhythm • lipid storage • GO:1901227 negative regulation of transcription by RNA polymerase II • circadian regulation of gene expression • transcription, DNA-templated • response to insulin • negative regulation of protein ubiquitination • regulation of circadian rhythm • regulation of DNA damage checkpoint • DNA damage induced protein phosphorylation • negative regulation of G protein-coupled receptor signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of glucocorticoid secretion • entrainment of circadian clock by photoperiod • blue light signaling pathway • Rhythm circadaidd • negative regulation of gluconeogenesis • positive regulation of protein ubiquitination • response to light stimulus • response to activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1407	n/a
Ensembl	ENSG00000008405	n/a
UniProt	Q16526	n/a
RefSeq (mRNA)	NM_004075	n/a
RefSeq (protein)	NP_004066 NP_004066.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CRY1 yw CRY1 a elwir hefyd yn Cryptochrome circadian regulator 1 a Cryptochrome 1 (Photolyase-like), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CRY1.

• DSPD
• PHLL1

Llyfryddiaeth

• "CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. ". Chronobiol Int. 2014. PMID 24548145.
• "Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. ". PLoS One. 2013. PMID 23626715.
• "Identification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function. ". J Biol Chem. 2012. PMID 22692217.
• "Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia. ". PLoS One. 2012. PMID 22470559.
• "Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia.". Haematologica. 2009. PMID 19181792.