CREBBP

CREBBP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JSP, 1LIQ, 1RDT, 1WO3, 1WO4, 1WO5, 1WO6, 1WO7, 2D82, 2KJE, 2KWF, 2L84, 2L85, 2LXS, 2LXT, 2RNY, 3DWY, 3P1C, 3P1D, 3P1E, 3P1F, 3SVH, 4A9K, 4N3W, 4N4F, 4NR4, 4NR5, 4NR6, 4NR7, 4NYV, 4NYW, 4NYX, 4OUF, 4TQN, 4TS8, 4WHU, 5JEM, 5I8B, 5I89, 5I86, 4YK0, 5CGP, 5I8G, 2N1A, 5I83, 1ZOQ, 5DBM
Dynodwyr
Cyfenwau	CREBBP, AW558298, CBP, CBP/p300, KAT3A, p300/CBP, RSTS, CREB binding protein, RSTS1, MKHK1
Dynodwyr allanol	OMIM: 600140 HomoloGene: 68393 GeneCards: CREBBP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • GO:0001105 transcription coactivator activity • MRF binding • zinc ion binding • p53 binding • transcription factor binding • chromatin binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001104 transcription coregulator activity • signal transducer activity • metal ion binding • histone acetyltransferase activity • damaged DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • acetyltransferase activity • acyltransferase activity • peptide N-acetyltransferase activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001106 transcription corepressor activity Cydrannau o'r gell • cytoplasm • nucleoplasm • histone acetyltransferase complex • cnewyllyn cell • nuclear body Prosesau biolegol • Notch signaling pathway • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • cellular response to UV • embryonic digit morphogenesis • N-terminal peptidyl-lysine acetylation • stimulatory C-type lectin receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of smoothened signaling pathway • histone acetylation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • regulation of cellular response to heat • transcription initiation from RNA polymerase II promoter • GO:0022415 viral process • positive regulation of type I interferon production • GO:0072468 signal transduction • protein acetylation • proses homeostatig • beta-catenin-TCF complex assembly • regulation of apoptotic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of lipid metabolic process • protein destabilization • regulation of myeloid cell differentiation • positive regulation of transcription of Notch receptor target • positive regulation of transforming growth factor beta receptor signaling pathway • positive regulation of Notch signaling pathway • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1387	n/a
Ensembl	ENSG00000005339	n/a
UniProt	Q92793	n/a
RefSeq (mRNA)	NM_001079846 NM_004380	n/a
RefSeq (protein)	NP_001073315 NP_004371	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CREBBP yw CREBBP a elwir hefyd yn CREB-binding protein a CREB binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CREBBP.

• CBP
• RSTS
• KAT3A
• RSTS1

Llyfryddiaeth

• "CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response. ". Haematologica. 2017. PMID 27979926.
• "Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP. ". Protein Sci. 2016. PMID 27699893.
• "Rubinstein-Taybi syndrome with multiple pilomatricomas: The first case diagnosed by CREBBP mutation analysis. ". J Dermatol Sci. 2016. PMID 27342041.
• "CREBBP mutations in individuals without Rubinstein-Taybi syndrome phenotype. ". Am J Med Genet A. 2016. PMID 27311832.
• "Analysis of mutations within the intron20 splice donor site of CREBBP in patients with and without classical RSTS.". Eur J Hum Genet. 2016. PMID 27165009.