CR1

CR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9
Dynodwyr
Cyfenwau	CR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group)
Dynodwyr allanol	OMIM: 120620 HomoloGene: 55474 GeneCards: CR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • virus receptor activity • complement component C3b receptor activity • complement component C4b receptor activity • complement component C3b binding • complement component C4b binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • cell surface • extracellular exosome • secretory granule membrane • ficolin-1-rich granule membrane Prosesau biolegol • negative regulation of complement activation, classical pathway • immune system process • positive regulation of serine-type endopeptidase activity • negative regulation of complement activation, alternative pathway • complement activation, classical pathway • viral entry into host cell • GO:0022415 viral process • negative regulation of serine-type endopeptidase activity • regulation of complement activation • complement receptor mediated signaling pathway • innate immune response • neutrophil degranulation • regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1378	n/a
Ensembl	ENSG00000203710	n/a
UniProt	P17927	n/a
RefSeq (mRNA)	NM_000573 NM_000651 NM_001381851	n/a
RefSeq (protein)	NP_000564 NP_000642 NP_001368780	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CR1 yw CR1 a elwir hefyd yn Complement C3b/C4b receptor 1 (Knops blood group) (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CR1.

• KN
• C3BR
• C4BR
• CD35

Llyfryddiaeth

• "Geographical distribution of complement receptor type 1 variants and their associated disease risk. ". PLoS One. 2017. PMID 28520715.
• "Complement receptor 1 gene polymorphisms are associated with cardiovascular risk. ". Atherosclerosis. 2017. PMID 28033544.
• "Complement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients. ". J Immunol Res. 2016. PMID 27981054.
• "Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function. ". PLoS One. 2016. PMID 26914463.
• "Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.". Elife. 2015. PMID 26650353.