CPSF6

CPSF6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3P5T, 3P6Y, 3Q2S, 3Q2T, 4B4N, 4U0A, 4U0B, 4WYM
Dynodwyr
Cyfenwau	CPSF6, CFIM, CFIM68, HPBRII-4, HPBRII-7, cleavage and polyadenylation specific factor 6, CFIM72
Dynodwyr allanol	OMIM: 604979 HomoloGene: 134126 GeneCards: CPSF6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • mRNA binding • RNA binding • nucleic acid binding • ribosomal large subunit binding • exon-exon junction complex binding Cydrannau o'r gell • paraspeckles • bilen • cnewyllyn cell • nucleoplasm • nuclear speck • mRNA cleavage factor complex • perichromatin fibrils • cytoplasm • mRNA cleavage and polyadenylation specificity factor complex • interchromatin granule • ribonucleoprotein complex Prosesau biolegol • mRNA polyadenylation • mRNA processing • protein tetramerization • positive regulation of RNA export from nucleus • protein heterotetramerization • pre-mRNA cleavage required for polyadenylation • mRNA alternative polyadenylation • messenger ribonucleoprotein complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11052	n/a
Ensembl	ENSG00000111605	n/a
UniProt	Q16630	n/a
RefSeq (mRNA)	NM_001300947 NM_007007	n/a
RefSeq (protein)	NP_001287876 NP_008938	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CPSF6 yw CPSF6 a elwir hefyd yn Cleavage and polyadenylation specific factor 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CPSF6.

• CFIM
• CFIM68
• CFIM72
• HPBRII-4
• HPBRII-7

Llyfryddiaeth

• "Structural basis of pre-mRNA recognition by the human cleavage factor Im complex. ". Cell Res. 2011. PMID 21483454.
• "Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export. ". Mol Biol Cell. 2009. PMID 19864460.
• "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation. ". Biochem Soc Trans. 2016. PMID 27528751.
• "A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. ". Proc Natl Acad Sci U S A. 2016. PMID 26858452.
• "Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length.". Cell Rep. 2012. PMID 22813749.