CPOX

CPOX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AEX
Dynodwyr
Cyfenwau	CPOX, CPO, CPX, HCP, coproporphyrinogen oxidase, COX, HARPO
Dynodwyr allanol	OMIM: 612732 HomoloGene: 76 GeneCards: CPOX
EC number	1.3.3.3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • coproporphyrinogen oxidase activity • protein homodimerization activity • structural constituent of eye lens • identical protein binding • oxidoreductase activity Cydrannau o'r gell • bilen • mitochondrial intermembrane space • mitocondria • mitochondrial inner membrane • cytosol • cytoplasm Prosesau biolegol • response to arsenic-containing substance • protoporphyrinogen IX biosynthetic process • porphyrin-containing compound biosynthetic process • response to iron ion • heme biosynthetic process • response to lead ion • response to inorganic substance • response to insecticide • response to methylmercury • protoporphyrinogen IX biosynthetic process from glutamate Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1371	n/a
Ensembl	n/a	n/a
UniProt	P36551	n/a
RefSeq (mRNA)	NM_000097	n/a
RefSeq (protein)	NP_000088	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CPOX yw CPOX a elwir hefyd yn Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial a Coproporphyrinogen oxidase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CPOX.

• CPO
• CPX
• HCP

Llyfryddiaeth

• "The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria. ". J Biochem. 2013. PMID 24078084.
• Hereditary Coproporphyria. 1993. PMID 23236641.
• "Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children. ". Neurotoxicol Teratol. 2012. PMID 22765978.
• "Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase. ". Bioorg Med Chem. 2011. PMID 21277781.
• "Identification of an AluY-mediated deletion of exon 5 in the CPOX gene by MLPA analysis in patients with hereditary coproporphyria.". Clin Genet. 2012. PMID 21231929.