CPB2

CPB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3D66, 3D67, 3D68, 3LMS, 4P10, 5HVG, 5HVH, 5HVF
Dynodwyr
Cyfenwau	CPB2, CPU, PCPB, TAFI, carboxypeptidase B2
Dynodwyr allanol	OMIM: 603101 HomoloGene: 55610 GeneCards: CPB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0070122 peptidase activity • hydrolase activity • zinc ion binding • carboxypeptidase activity • metallopeptidase activity • metallocarboxypeptidase activity Cydrannau o'r gell • extracellular exosome • extracellular space • extracellular region Prosesau biolegol • blood coagulation • negative regulation of hepatocyte proliferation • positive regulation of extracellular matrix constituent secretion • liver regeneration • cellular response to glucose stimulus • negative regulation of plasminogen activation • negative regulation of fibrinolysis • response to heat • hemostasis • proteolysis • fibrinolysis • regulation of complement activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1361	n/a
Ensembl	ENSG00000080618	n/a
UniProt	Q96IY4	n/a
RefSeq (mRNA)	NM_016413 NM_001278541 NM_001872	n/a
RefSeq (protein)	NP_001265470 NP_001863	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CPB2 yw CPB2 a elwir hefyd yn Carboxypeptidase B2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q14.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CPB2.

• CPU
• PCPB
• TAFI

Llyfryddiaeth

• "Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis. ". PLoS One. 2017. PMID 28552956.
• "Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment. ". Clin Exp Metastasis. 2017. PMID 28124276.
• "Thrombin activatable fibrinolysis inhibitor as a bleeding predictor in liver transplantation: a pilot observational study. ". Rev Bras Ter Intensiva. 2016. PMID 27410412.
• "Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. ". J Thromb Haemost. 2016. PMID 27279497.
• "Meta-analysis of TAFI polymorphisms and risk of cardiovascular and cerebrovascular diseases.". Genet Mol Res. 2016. PMID 27173177.