COX17

COX17
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2L0Y, 2LGQ, 2RN9, 2RNB
Dynodwyr
Cyfenwau	COX17, cytochrome c oxidase copper chaperone, cytochrome c oxidase copper chaperone COX17
Dynodwyr allanol	OMIM: 604813 HomoloGene: 38089 GeneCards: COX17
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • copper ion binding • GO:0001948, GO:0016582 protein binding • metal ion binding • cuprous ion binding • copper chaperone activity Cydrannau o'r gell • mitocondria • mitochondrial intermembrane space • cytoplasm Prosesau biolegol • heart development • brain development • generation of precursor metabolites and energy • copper ion transport • positive regulation of cell population proliferation • mitochondrial cytochrome c oxidase assembly • positive regulation of cytochrome-c oxidase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10063	n/a
Ensembl	ENSG00000138495	n/a
UniProt	Q14061	n/a
RefSeq (mRNA)	NM_005694	n/a
RefSeq (protein)	NP_005685 NP_001368931 NP_001368932	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn COX17 yw COX17 a elwir hefyd yn Cytochrome c oxidase copper chaperone a COX17, cytochrome c oxidase copper chaperone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q13.33.

Llyfryddiaeth

• "Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents. ". Protein Expr Purif. 2007. PMID 17208454.
• "A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p. ". Biochem Biophys Res Commun. 2004. PMID 15504366.
• "A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry. ". J Inorg Biochem. 2016. PMID 27235272.
• "Glutathione selectively modulates the binding of platinum drugs to human copper chaperone Cox17. ". Biochem J. 2015. PMID 26399480.
• "Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective.". J Biol Chem. 2011. PMID 21816817.