COMP

COMP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3FBY
Dynodwyr
Cyfenwau	COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein, TSP5, CTS2
Dynodwyr allanol	OMIM: 600310 HomoloGene: 74 GeneCards: COMP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protease binding • calcium ion binding • heparan sulfate proteoglycan binding • heparin binding • extracellular matrix structural constituent • GO:0001948, GO:0016582 protein binding • collagen binding • integrin binding • BMP binding • proteoglycan binding Cydrannau o'r gell • GO:0005578 extracellular matrix • extracellular exosome • extracellular space • extracellular region • GO:0009327 protein-containing complex • collagen-containing extracellular matrix Prosesau biolegol • animal organ morphogenesis • growth plate cartilage development • skeletal system development • cell adhesion • extracellular matrix organization • negative regulation of apoptotic process • limb development • GO:0097285 apoptotic process • ossification • chondrocyte development • endochondral bone growth • response to unfolded protein • blood coagulation • protein secretion • multicellular organism aging • regulation of gene expression • vascular associated smooth muscle contraction • protein processing • collagen fibril organization • bone mineralization • regulation of bone mineralization • BMP signaling pathway • multicellular organism growth • chondrocyte proliferation • tendon development • skin development • artery morphogenesis • musculoskeletal movement • neuromuscular process • cartilage development • bone morphogenesis • platelet aggregation • vascular associated smooth muscle cell development • bone growth • negative regulation of hemostasis • positive regulation of chondrocyte proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1311	n/a
Ensembl	ENSG00000105664	n/a
UniProt	P49747	n/a
RefSeq (mRNA)	NM_000095	n/a
RefSeq (protein)	NP_000086	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn COMP yw COMP a elwir hefyd yn Cartilage oligomeric matrix protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn COMP.

• MED
• EDM1
• EPD1
• TSP5
• PSACH
• THBS5

Llyfryddiaeth

• "The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder. ". J Clin Psychopharmacol. 2017. PMID 27930497.
• "Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study. ". Eur J Appl Physiol. 2016. PMID 27699484.
• "[THE COMPARATIVE ANALYSIS OF LEVEL OF OLIGOMERIC MATRIX PROTEIN OF CARTILAGE IN BLOOD SERUM OF PATIENTS WITH DISEASES OF MUSCULO-SKELETAL SYSTEM]. ". Klin Lab Diagn. 2016. PMID 27455560.
• "Identification of two novel mutations in the COMP gene in six families with pseudoachondroplasia. ". Mol Med Rep. 2016. PMID 27432013.
• "The effect of vigorous running and cycling on serum COMP, lubricin, and femoral cartilage thickness: a pilot study.". Eur J Appl Physiol. 2016. PMID 27251407.