COMMD1

COMMD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H2M
Dynodwyr
Cyfenwau	COMMD1, C2orf5, MURR1, copper metabolism domain containing 1
Dynodwyr allanol	OMIM: 607238 HomoloGene: 17604 GeneCards: COMMD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • phosphatidylinositol-3,5-bisphosphate binding • metal ion binding • phosphatidylinositol-3,4-bisphosphate binding • phosphatidic acid binding • GO:0001948, GO:0016582 protein binding • identical protein binding • phosphatidylinositol-4,5-bisphosphate binding • copper ion binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding Cydrannau o'r gell • cytoplasm • recycling endosome • endosome • bilen • Cul2-RING ubiquitin ligase complex • early endosome • endosome membrane • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • negative regulation of sodium ion transmembrane transport • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of protein localization to cell surface • plasma membrane to endosome transport • regulation of proteasomal ubiquitin-dependent protein catabolic process • protein transport • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • Golgi to plasma membrane transport • post-translational protein modification • copper ion homeostasis • protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	150684	n/a
Ensembl	ENSG00000173163	n/a
UniProt	Q8N668	n/a
RefSeq (mRNA)	NM_152516 NM_001321781 NM_001321782 NM_001371765	n/a
RefSeq (protein)	NP_001308710 NP_001308711 NP_689729 NP_001358694	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn COMMD1 yw COMMD1 a elwir hefyd yn COMM domain-containing protein 1 a Copper metabolism domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn COMMD1.

• MURR1
• C2orf5

Llyfryddiaeth

• "COMMD1 and ion transport proteins: what is the COMMection? Focus on "COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination". ". Am J Physiol Cell Physiol. 2013. PMID 23677795.
• "Expression and localization of COMMD1 proteins in human placentas from women with preeclampsia. ". Yonsei Med J. 2013. PMID 23364987.
• "Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery. ". Mol Hum Reprod. 2016. PMID 26733542.
• "Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma. ". PLoS One. 2014. PMID 24625556.
• "COMMD1 modulates noxious inflammation in cystic fibrosis.". Int J Biochem Cell Biol. 2013. PMID 23892095.