COL18A1

COL18A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BNL, 3HON, 3HSH
Dynodwyr
Cyfenwau	COL18A1, KNO, KNO1, KS, Collagen, type XVIII, alpha 1, collagen type XVIII alpha 1, collagen type XVIII alpha 1 chain, GLCC
Dynodwyr allanol	OMIM: 120328 HomoloGene: 7673 GeneCards: COL18A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • structural molecule activity • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • extracellular matrix structural constituent • extracellular matrix structural constituent conferring tensile strength Cydrannau o'r gell • collagen • endoplasmic reticulum lumen • GO:0005578 extracellular matrix • basement membrane • extracellular exosome • extracellular space • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • positive regulation of cell migration • endothelial cell morphogenesis • response to hydrostatic pressure • extracellular matrix organization • positive regulation of endothelial cell apoptotic process • cell adhesion • angiogenesis • positive regulation of cell population proliferation • animal organ morphogenesis • collagen catabolic process • golwg • negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	80781	n/a
Ensembl	ENSG00000182871	n/a
UniProt	P39060	n/a
RefSeq (mRNA)	NM_130445 NM_030582 NM_130444 NM_001379500	n/a
RefSeq (protein)	NP_085059 NP_569711 NP_569712 NP_001366429	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn COL18A1 yw COL18A1 a elwir hefyd yn Collagen type XVIII alpha 1 chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn COL18A1.

• KS
• KNO
• KNO1

Llyfryddiaeth

• "Expression of Proinflammatory Factors, Proangiogenic Factors and Endostatin in Patients with Heart Failure and Different Grades of Collateral Circulation Development. ". Adv Clin Exp Med. 2015. PMID 26771970.
• "Genetic polymorphisms in COL18A1 influence the development of osteosarcoma. ". Int J Clin Exp Pathol. 2015. PMID 26617886.
• "Familial epilepsy with anterior polymicrogyria as a presentation of COL18A1 mutations. ". Eur J Med Genet. 2017. PMID 28602933.
• "Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients. ". Matrix Biol. 2017. PMID 27746220.
• "Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome.". Clin Exp Rheumatol. 2016. PMID 27214260.