CNOT7

CNOT7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D5R, 4GMJ
Dynodwyr
Cyfenwau	CNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7
Dynodwyr allanol	OMIM: 604913 HomoloGene: 49011 GeneCards: CNOT7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nuclease activity • nucleic acid binding • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • 3'-5'-exoribonuclease activity • signal transducer activity • poly(A)-specific ribonuclease activity • exonuclease activity • RNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • hydrolase activity • metal ion binding • transcription factor binding • GO:0001106 transcription corepressor activity Cydrannau o'r gell • cnewyllyn cell • CCR4-NOT complex • cytosol • bilen • nuclear body • P-body • cytoplasm • nuclear speck • CCR4-NOT core complex • host cell PML body Prosesau biolegol • negative regulation of cell population proliferation • negative regulation of gene expression • exonucleolytic catabolism of deadenylated mRNA • deadenylation-dependent decapping of nuclear-transcribed mRNA • nucleic acid phosphodiester bond hydrolysis • P-body assembly • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • GO:0009373 regulation of transcription, DNA-templated • positive regulation of cell population proliferation • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of mRNA catabolic process • gene silencing by miRNA • regulation of translation • nuclear-transcribed mRNA poly(A) tail shortening • GO:0072468 signal transduction • gene silencing • transcription, DNA-templated • RNA phosphodiester bond hydrolysis, exonucleolytic • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of tyrosine phosphorylation of STAT protein • positive regulation of viral genome replication • GO:0045996 negative regulation of transcription, DNA-templated • defense response to virus • negative regulation of type I interferon-mediated signaling pathway • carbohydrate metabolic process • negative regulation of translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	29883	n/a
Ensembl	ENSG00000198791	n/a
UniProt	Q9UIV1	n/a
RefSeq (mRNA)	NM_013354 NM_054026 NM_001322087 NM_001322088 NM_001322089 NM_001322090 NM_001322091 NM_001322092 NM_001322093 NM_001322094 NM_001322095 NM_001322096 NM_001322097 NM_001322098 NM_001322099 NM_001322100	n/a
RefSeq (protein)	NP_001309016 NP_001309017 NP_001309018 NP_001309019 NP_001309020 NP_001309021 NP_001309022 NP_001309023 NP_001309024 NP_001309025 NP_001309026 NP_001309027 NP_001309028 NP_001309029 NP_037486 NP_473367	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CNOT7 yw CNOT7 a elwir hefyd yn CCR4-NOT transcription complex subunit 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CNOT7.

• CAF1
• CAF-1
• Caf1a
• hCAF-1

Llyfryddiaeth

• "Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex. ". Front Genet. 2013. PMID 24391663.
• "A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity. ". Nucleic Acids Res. 2014. PMID 24170810.
• "Alternative splicing of CNOT7 diversifies CCR4-NOT functions. ". Nucleic Acids Res. 2017. PMID 28591869.
• "Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach. ". Protein Cell. 2015. PMID 26518565.
• "Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.". Bioorg Med Chem Lett. 2015. PMID 26299350.