CNKSR2

CNKSR2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EAN, 3BS5
Dynodwyr
Cyfenwau	CNKSR2, CNK2, KSR2, MAGUIN, connector enhancer of kinase suppressor of Ras 2, MRXSHG
Dynodwyr allanol	OMIM: 300724 HomoloGene: 8956 GeneCards: CNKSR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • identical protein binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • neuron projection • neuronal cell body • postsynaptic membrane • extracellular exosome • bilen • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse • extrinsic component of postsynaptic density membrane Prosesau biolegol • regulation of signal transduction • postsynapse organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	22866	n/a
Ensembl	ENSG00000149970	n/a
UniProt	Q8WXI2	n/a
RefSeq (mRNA)	NM_001168647 NM_001168648 NM_001168649 NM_014927 NM_001330770 NM_001330771 NM_001330772 NM_001330773	n/a
RefSeq (protein)	NP_001162118 NP_001162119 NP_001162120 NP_001317699 NP_001317700 NP_001317701 NP_001317702 NP_055742	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CNKSR2 yw CNKSR2 a elwir hefyd yn Connector enhancer of kinase suppressor of Ras 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp22.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CNKSR2.

• CNK2
• KSR2
• MAGUIN
• MRXSHG

Llyfryddiaeth

• "The kinases LF4 and CNK2 control ciliary length by feedback regulation of assembly and disassembly rates. ". Curr Biol. 2013. PMID 24184104.
• "Loss-of-Function CNKSR2 Mutation Is a Likely Cause of Non-Syndromic X-Linked Intellectual Disability. ". Mol Syndromol. 2012. PMID 22511892.
• "CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures. ". Am J Med Genet A. 2015. PMID 25754917.
• "Absent CNKSR2 causes seizures and intellectual, attention, and language deficits. ". Ann Neurol. 2014. PMID 25223753.
• "The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.". Curr Biol. 2014. PMID 24656827.