CLTC

CLTC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2XZG, 4G55
Dynodwyr
Cyfenwau	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
Dynodwyr allanol	OMIM: 118955 HomoloGene: 3572 GeneCards: CLTC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • double-stranded RNA binding • protein kinase binding • structural molecule activity • RNA binding • clathrin light chain binding • disordered domain specific binding • low-density lipoprotein particle receptor binding • ubiquitin-specific protease binding Cydrannau o'r gell • extracellular vesicle • cytosol • clathrin-coated endocytic vesicle membrane • clathrin coat of coated pit • trans-Golgi network membrane • clathrin coat of trans-Golgi network vesicle • focal adhesion • melanosome • Cellbilen • endolysosome membrane • clathrin-coated pit • extracellular exosome • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • clathrin-coated vesicle • GO:0005578 extracellular matrix • bilen • mitotic spindle microtubule • cytoplasm • lysosome • endosome • spindle • Cytosgerbwd • clathrin coat • clathrin complex • GO:0009327 protein-containing complex • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • mitotic spindle • intracellular anatomical structure Prosesau biolegol • antigen processing and presentation of exogenous peptide antigen via MHC class II • transferrin transport • receptor internalization • negative regulation of protein localization to plasma membrane • retrograde transport, endosome to Golgi • osteoblast differentiation • vesicle-mediated transport • negative regulation of hyaluronan biosynthetic process • intracellular protein transport • Wnt signaling pathway, planar cell polarity pathway • regulation of mitotic spindle organization • autophagy • microtubule-based movement • cell cycle • Cellraniad • membrane organization • GO:0007067 Mitosis • receptor-mediated endocytosis • low-density lipoprotein particle receptor catabolic process • low-density lipoprotein particle clearance • clathrin coat assembly • clathrin-dependent endocytosis • amyloid-beta clearance by transcytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1213	n/a
Ensembl	ENSG00000141367	n/a
UniProt	Q00610	n/a
RefSeq (mRNA)	NM_001288653 NM_004859	n/a
RefSeq (protein)	NP_001275582 NP_004850	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLTC yw CLTC a elwir hefyd yn Clathrin heavy chain 1 a Clathrin heavy chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLTC.

• Hc
• CHC
• CHC17
• CLH-17
• CLTCL2

Llyfryddiaeth

• "Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge. ". Eur J Immunol. 2016. PMID 27405273.
• "Clathrin mediates infectious hepatitis C virus particle egress. ". J Virol. 2015. PMID 25631092.
• "CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling. ". Cancer Lett. 2013. PMID 23228632.
• "Clathrin is required for postmitotic Golgi reassembly. ". FASEB J. 2012. PMID 21965600.
• "A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit.". J Clin Endocrinol Metab. 2011. PMID 21917865.