CLIC4

CLIC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AHE, 2D2Z, 3OQS
Dynodwyr
Cyfenwau	CLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
Dynodwyr allanol	OMIM: 606536 HomoloGene: 8490 GeneCards: CLIC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • voltage-gated ion channel activity • GO:0001948, GO:0016582 protein binding • glutathione transferase activity • chloride channel activity Cydrannau o'r gell • cytoplasm • integral component of membrane • cytosol • centrosome • bilen • cell-cell junction • nuclear matrix • microtubule cytoskeleton • Cellbilen • apical part of cell • intracellular anatomical structure • chloride channel complex • microtubule organizing center • microvillus • cell surface • cell junction • midbody • mitocondria • actin cytoskeleton • perinuclear region of cytoplasm • extracellular exosome • Cytosgerbwd • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • cnewyllyn cell Prosesau biolegol • cellular response to calcium ion • cell differentiation • multicellular organism growth • regulation of ion transmembrane transport • endothelial cell morphogenesis • cludo ïon • keratinocyte differentiation • vacuolar acidification • negative regulation of cell migration • fertilization • establishment or maintenance of apical/basal cell polarity • chloride transport • branching morphogenesis of an epithelial tube • retina vasculature morphogenesis in camera-type eye • regulation of cytoskeleton organization • angiogenesis • glutathione metabolic process • chloride transmembrane transport • GO:0015915 transport • cludo transmembrane rhwng ïonau Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25932	n/a
Ensembl	ENSG00000169504	n/a
UniProt	Q9Y696	n/a
RefSeq (mRNA)	NM_013943	n/a
RefSeq (protein)	NP_039234	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLIC4 yw CLIC4 a elwir hefyd yn Chloride intracellular channel 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLIC4.

• H1
• huH1
• p64H1
• CLIC4L
• MTCLIC

Llyfryddiaeth

• "CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. ". Carcinogenesis. 2012. PMID 22387366.
• "CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. ". Oncol Rep. 2009. PMID 19639201.
• "CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma. ". Oncogene. 2014. PMID 23416981.
• "Suppression of CLIC4/mtCLIC enhances hydrogen peroxide-induced apoptosis in C6 glioma cells. ". Oncol Rep. 2013. PMID 23380911.
• "Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis in human glioma U251 cells under starvation.". PLoS One. 2012. PMID 22761775.