CLIC1

CLIC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N
Dynodwyr
Cyfenwau	CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
Dynodwyr allanol	OMIM: 602872 HomoloGene: 20343 GeneCards: CLIC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • voltage-gated ion channel activity • GO:0001948, GO:0016582 protein binding • chloride channel activity • cadherin binding • glutathione transferase activity Cydrannau o'r gell • cytoplasm • integral component of membrane • fesigl • nuclear membrane • blood microparticle • nuclear envelope • bilen • Cellbilen • chloride channel complex • mitocondria • brush border • perinuclear region of cytoplasm • extracellular exosome • cnewyllyn cell • extracellular space Prosesau biolegol • regulation of ion transmembrane transport • cludo ïon • regulation of cell cycle • regulation of mitochondrial membrane potential • positive regulation of osteoblast differentiation • chloride transport • platelet aggregation • GO:0072468 signal transduction • chloride transmembrane transport • glutathione metabolic process • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1192	n/a
Ensembl	ENSG00000213719 ENSG00000223639 ENSG00000226248 ENSG00000226651 ENSG00000226417 ENSG00000230685 ENSG00000206394	n/a
UniProt	O00299	n/a
RefSeq (mRNA)	NM_001288 NM_001287593 NM_001287594	n/a
RefSeq (protein)	NP_001274522 NP_001274523 NP_001279	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CLIC1 yw CLIC1 a elwir hefyd yn Chloride intracellular channel 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CLIC1.

• G6
• CL1C1
• NCC27

Llyfryddiaeth

• "MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. ". Biochem Biophys Res Commun. 2017. PMID 29061300.
• "Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells. ". Cancer Sci. 2017. PMID 28378944.
• "CLIC1 overexpression is associated with poor prognosis in pancreatic ductal adenocarcinomas. ". J Cancer Res Ther. 2016. PMID 27461670.
• "Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. ". Oncotarget. 2015. PMID 26429879.
• "Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer.". Med Oncol. 2015. PMID 25920608.