CITED2

CITED2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P4Q, 1R8U
Dynodwyr
Cyfenwau	CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Dynodwyr allanol	OMIM: 602937 HomoloGene: 4433 GeneCards: CITED2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • LBD domain binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • protein domain specific binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • adrenal cortex formation • positive regulation of transforming growth factor beta receptor signaling pathway • cell differentiation • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • positive regulation of cell-cell adhesion • embryonic heart tube left/right pattern formation • ventricular septum morphogenesis • outflow tract morphogenesis • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • spleen development • negative regulation of gene expression • transcription, DNA-templated • response to fluid shear stress • response to estrogen • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • heart development • determination of left/right symmetry • GO:1901313 positive regulation of gene expression • negative regulation of cell migration • positive regulation of cell cycle • regulation of animal organ formation • sex-determination system • positive regulation of peroxisome proliferator activated receptor signaling pathway • liver development • left/right pattern formation • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • left/right axis specification • positive regulation of male gonad development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • positive regulation of nucleic acid-templated transcription • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10370	n/a
Ensembl	ENSG00000164442	n/a
UniProt	Q99967	n/a
RefSeq (mRNA)	NM_006079 NM_001168388 NM_001168389	n/a
RefSeq (protein)	NP_001161860 NP_001161861 NP_006070	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CITED2 yw CITED2 a elwir hefyd yn Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CITED2.

• ASD8
• MRG1
• VSD2
• MRG-1
• P35SRJ

Llyfryddiaeth

• "Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. ". Cell Tissue Res. 2017. PMID 28084522.
• "CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance. ". Cancer Sci. 2016. PMID 27627783.
• "Functional Analyses of a Novel CITED2 Nonsynonymous Mutation in Chinese Tibetan Patients with Congenital Heart Disease. ". Pediatr Cardiol. 2017. PMID 28687891.
• "Knockdown of Cbp/P300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 inhibits cell division and increases apoptosis in gastric cancer. ". J Surg Res. 2017. PMID 28501104.
• "CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese Children.". DNA Cell Biol. 2017. PMID 28436679.