CHRNB2

CHRNB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K58, 2K59, 2KSR, 2LM2
Dynodwyr
Cyfenwau	CHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
Dynodwyr allanol	OMIM: 118507 HomoloGene: 595 GeneCards: CHRNB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • acetylcholine binding • acetylcholine receptor activity • ion channel activity • GO:0001948, GO:0016582 protein binding • ligand-gated ion channel activity • protein heterodimerization activity • extracellular ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity • transmembrane signaling receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cydrannau o'r gell • acetylcholine-gated channel complex • integral component of membrane • postsynaptic membrane • bilen • Cellbilen • synapse • cell junction • external side of plasma membrane • integral component of plasma membrane • neuron projection • plasma membrane raft • dopaminergic synapse • cholinergic synapse • integral component of presynaptic membrane • integral component of postsynaptic specialization membrane Prosesau biolegol • visual learning • regulation of synaptic transmission, dopaminergic • adwaith i gocên • smooth muscle contraction • regulation of circadian sleep/wake cycle, REM sleep • regulation of dopamine secretion • response to hypoxia • associative learning • gwybyddiaeth • locomotory behavior • protein heterooligomerization • central nervous system neuron axonogenesis • optic nerve morphogenesis • regulation of synapse assembly • regulation of membrane potential • response to nicotine • membrane depolarization • nervous system process • synaptic transmission, cholinergic • cludo ïon • sensory perception of sound • learning • Cof • negative regulation of action potential • regulation of dopamine metabolic process • behavioral response to nicotine • regulation of dendrite morphogenesis • B cell activation • neuromuscular synaptic transmission • synaptic transmission involved in micturition • positive regulation of dopamine secretion • positive regulation of B cell proliferation • regulation of circadian sleep/wake cycle, non-REM sleep • vestibulocochlear nerve development • conditioned taste aversion • GO:0015915 transport • social behavior • action potential • sensory perception of pain • lateral geniculate nucleus development • positive regulation of synaptic transmission, dopaminergic • response to ethanol • central nervous system projection neuron axonogenesis • calcium ion transport • GO:0072468 signal transduction • golwg • cludo transmembrane rhwng ïonau • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • acetylcholine receptor signaling pathway • chemical synaptic transmission • response to acetylcholine • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1141	n/a
Ensembl	ENSG00000160716	n/a
UniProt	P17787	n/a
RefSeq (mRNA)	NM_000748	n/a
RefSeq (protein)	NP_000739	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHRNB2 yw CHRNB2 a elwir hefyd yn Cholinergic receptor nicotinic beta 2 subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHRNB2.

• EFNL3
• nAChRB2

Llyfryddiaeth

• "The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. ". Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID 25640319.
• "Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. ". Pharmacogenomics J. 2012. PMID 21606948.
• "NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit. ". Biochim Biophys Acta. 2010. PMID 20441771.
• "Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. ". Nicotine Tob Res. 2010. PMID 20371741.
• "Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch.". Cancer Epidemiol Biomarkers Prev. 2009. PMID 19755656.