CHRNA1

CHRNA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4ZJS
Dynodwyr
Cyfenwau	CHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
Dynodwyr allanol	OMIM: 100690 HomoloGene: 59 GeneCards: CHRNA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • extracellular ligand-gated ion channel activity • acetylcholine receptor activity • ligand-gated ion channel activity • ion channel activity • acetylcholine binding • acetylcholine-gated cation-selective channel activity • transmembrane signaling receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cydrannau o'r gell • integral component of membrane • bilen • synapse • cell junction • Cellbilen • neuromuscular junction • cell surface • postsynaptic membrane • acetylcholine-gated channel complex • integral component of postsynaptic specialization membrane • integral component of plasma membrane • neuron projection Prosesau biolegol • muscle cell cellular homeostasis • neuron cellular homeostasis • regulation of membrane potential • skeletal muscle contraction • response to nicotine • cation transport • synaptic transmission, cholinergic • cludo ïon • skeletal muscle tissue growth • neuromuscular synaptic transmission • neuromuscular process • neuromuscular junction development • musculoskeletal movement • GO:0072468 signal transduction • neuronal action potential • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • cludo transmembrane rhwng ïonau • chemical synaptic transmission • nervous system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1134	n/a
Ensembl	ENSG00000138435	n/a
UniProt	P02708	n/a
RefSeq (mRNA)	NM_001039523 NM_000079	n/a
RefSeq (protein)	NP_000070 NP_001034612	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHRNA1 yw CHRNA1 a elwir hefyd yn Cholinergic receptor nicotinic alpha 1 subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHRNA1.

• ACHRA
• ACHRD
• CHRNA
• CMS1A
• CMS1B
• CMS2A
• FCCMS
• SCCMS

Llyfryddiaeth

• "High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. ". PLoS One. 2016. PMID 27649498.
• "Effect of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides on rabies virus infection in neuronal cells. ". Neuropeptides. 2016. PMID 26656837.
• "Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes. ". Biochem Biophys Res Commun. 2015. PMID 25888793.
• "Expression of a highly antigenic and native-like folded extracellular domain of the human α1 subunit of muscle nicotinic acetylcholine receptor, suitable for use in antigen specific therapies for Myasthenia Gravis. ". PLoS One. 2013. PMID 24376846.
• "High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection.". Ann Surg Oncol. 2013. PMID 23775407.