CHKA

CHKA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CKO, 2CKP, 2CKQ, 2I7Q, 3F2R, 3G15, 3ZM9, 4BR3, 4CG8, 4CG9, 4CGA, 4DA5, 5AFV, 5EQE, 5EQP, 5EQY, 5FTG
Dynodwyr
Cyfenwau	CHKA, CHK, CK, CKI, EK, choline kinase alpha
Dynodwyr allanol	OMIM: 118491 HomoloGene: 88575 GeneCards: CHKA
EC number	2.7.1.82
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein homodimerization activity • cholinesterase activity • signal transducer activity • choline binding • kinase activity • ATP binding • ethanolamine kinase activity • choline kinase activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • lipid transport • ethanolamine metabolic process • choline metabolic process • phosphorylation • lipid metabolism • response to 3-methylcholanthrene • phospholipid biosynthetic process • response to toxic substance • CDP-choline pathway • GO:0072468 signal transduction • phosphatidylcholine biosynthetic process • phosphatidylethanolamine biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1119	n/a
Ensembl	ENSG00000110721	n/a
UniProt	P35790	n/a
RefSeq (mRNA)	NM_001277 NM_212469 NM_001376219 NM_001376220 NM_001376221 NM_001376222	n/a
RefSeq (protein)	NP_001268 NP_997634 NP_001363148 NP_001363149 NP_001363150 NP_001363151	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHKA yw CHKA a elwir hefyd yn Choline kinase alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHKA.

• CK
• EK
• CHK
• CKI

Llyfryddiaeth

• "Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. ". Gastroenterology. 2017. PMID 28065789.
• "Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. ". Mol Cancer Ther. 2016. PMID 26769123.
• "Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target. ". J Natl Cancer Inst. 2016. PMID 26657335.
• "Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. ". NMR Biomed. 2015. PMID 26503172.
• "Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells.". PLoS One. 2015. PMID 26496360.