CHFR

CHFR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LGP, 1LGQ, 2XOC, 2XOY, 2XOZ, 2XP0
Dynodwyr
Cyfenwau	CHFR, RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, checkpoint with forkhead and ring finger domains
Dynodwyr allanol	OMIM: 605209 HomoloGene: 10078 GeneCards: CHFR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity Cydrannau o'r gell • PML body • cnewyllyn cell Prosesau biolegol • mitotic cell cycle checkpoint signaling • Cellraniad • GO:0007067 Mitosis • cell cycle • protein polyubiquitination • modification-dependent protein catabolic process • positive regulation of protein ubiquitination • protein destabilization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55743	n/a
Ensembl	ENSG00000072609	n/a
UniProt	Q96EP1	n/a
RefSeq (mRNA)	NM_018223 NM_001161344 NM_001161345 NM_001161346 NM_001161347	n/a
RefSeq (protein)	NP_001154816 NP_001154817 NP_001154818 NP_001154819 NP_060693	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHFR yw CHFR a elwir hefyd yn E3 ubiquitin-protein ligase CHFR a Checkpoint with forkhead and ring finger domains (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHFR.

• RNF116
• RNF196

Llyfryddiaeth

• "CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer. ". Clin Cancer Res. 2014. PMID 24928946.
• "Association between CHFR methylation and chemosensitivity of paclitaxel in advanced gastric cancer. ". Med Oncol. 2014. PMID 24639283.
• "CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome. ". Genes Chromosomes Cancer. 2016. PMID 26542416.
• "CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer. ". Discov Med. 2015. PMID 25828518.
• "Aberrant expression of the CHFR prophase checkpoint gene in human B-cell non-Hodgkin lymphoma.". Leuk Res. 2015. PMID 25798877.