CHEK2

CHEK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U, 3I6W, 4A9R, 4A9S, 4A9T, 4A9U, 4BDA, 4BDB, 4BDC, 4BDD, 4BDE, 4BDF, 4BDG, 4BDH, 4BDI, 4BDJ, 4BDK, 2WTI, 2WTJ, 2XK9
Dynodwyr
Cyfenwau	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
Dynodwyr allanol	OMIM: 604373 HomoloGene: 38289 GeneCards: CHEK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • metal ion binding • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding • ATP binding • ubiquitin protein ligase binding • kinase activity Cydrannau o'r gell • PML body • Golgi apparatus • nucleoplasm • telomere • cnewyllyn cell • cytoplasm Prosesau biolegol • positive regulation of protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • cellular response to bisphenol A • negative regulation of DNA damage checkpoint • phosphorylation • signal transduction in response to DNA damage • replicative senescence • DNA damage checkpoint signaling • protein stabilization • transcription, DNA-templated • cellular response to DNA damage stimulus • Cellraniad • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • mitotic spindle assembly • G2/M transition of mitotic cell cycle • intrinsic apoptotic signaling pathway in response to DNA damage • DNA damage induced protein phosphorylation • GO:1903362 regulation of protein catabolic process • protein autophosphorylation • cell cycle • positive regulation of anoikis • response to gamma radiation • GO:0097285 apoptotic process • double-strand break repair • GO:0100026 DNA repair • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of signal transduction by p53 class mediator • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0035404 peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of apoptotic process • cellular response to gamma radiation • response to glycoside • mitotic DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11200	n/a
Ensembl	ENSG00000183765	n/a
UniProt	O96017	n/a
RefSeq (mRNA)	NM_001005735 NM_001257387 NM_007194 NM_145862 NM_001349956	n/a
RefSeq (protein)	NP_001005735 NP_001244316 NP_009125 NP_665861 NP_001336885	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHEK2 yw CHEK2 a elwir hefyd yn Serine/threonine-protein kinase Chk2 a Checkpoint kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHEK2.

• CDS1
• CHK2
• LFS2
• RAD53
• hCds1
• HuCds1
• PP1425

Llyfryddiaeth

• "Condensin recruitment to chromatin is inhibited by Chk2 kinase in response to DNA damage. ". Cell Cycle. 2016. PMID 27792460.
• "Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers. ". Cancer Genet. 2016. PMID 27751358.
• "Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database. ". FEBS Lett. 2016. PMID 27716909.
• "Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified in Breast Cancer Patients from Balochistan. ". Asian Pac J Cancer Prev. 2016. PMID 27510020.
• "Case report of a Li-Fraumeni syndrome-like phenotype with a de novo mutation in CHEK2.". Medicine (Baltimore). 2016. PMID 27442652.