CHD5

CHD5
Dynodwyr
Cyfenwau	CHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
Dynodwyr allanol	OMIM: 610771 HomoloGene: 56712 GeneCards: CHD5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • GO:0008026 helicase activity • metal ion binding • H3K27me3 modified histone binding • hydrolase activity • ATP binding Cydrannau o'r gell • NuRD complex • bilen • GO:0035328 heterochromatin • cnewyllyn cell • nucleoplasm • cytosol • nuclear speck Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • histone H3-K27 trimethylation • positive regulation of signal transduction by p53 class mediator • transcription, DNA-templated • nervous system development • spermatogenesis • histone H4 acetylation • cerebral cortex neuron differentiation • negative regulation of cell population proliferation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26038	n/a
Ensembl	ENSG00000116254	n/a
UniProt	Q8TDI0	n/a
RefSeq (mRNA)	NM_015557	n/a
RefSeq (protein)	NP_056372	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHD5 yw CHD5 a elwir hefyd yn Chromodomain-helicase-DNA-binding protein 5 a Chromodomain helicase DNA binding protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHD5.

• CHD-5

Llyfryddiaeth

• "The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. ". J Biol Chem. 2014. PMID 24923445.
• "CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma. ". Liver Int. 2014. PMID 24529164.
• "CHD5 is a potential tumor suppressor in non small cell lung cancer (NSCLC). ". Gene. 2017. PMID 28400267.
• "The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. ". Oncotarget. 2016. PMID 26943038.
• "Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.". J Biol Regul Homeost Agents. 2015. PMID 26753653.