CEL

CEL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F6W, 1JMY
Dynodwyr
Cyfenwau	CEL, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, Bile salt-dependent lipase, carboxyl ester lipase
Dynodwyr allanol	OMIM: 114840 HomoloGene: 37529 GeneCards: CEL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heparin binding • acylglycerol lipase activity • catalytic activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • hydrolase activity, acting on ester bonds • GO:0004091 carboxylic ester hydrolase activity • triglyceride lipase activity • sterol esterase activity • signaling receptor activity • neurexin family protein binding Cydrannau o'r gell • cytoplasm • extracellular region • extracellular exosome • extracellular space • integral component of plasma membrane • cell surface • synapse • presynapse Prosesau biolegol • fatty acid catabolic process • lipid digestion • protein esterification • lipid metabolism • cholesterol catabolic process • pancreatic juice secretion • intestinal lipid catabolic process • lipid catabolic process • intestinal cholesterol absorption • triglyceride metabolic process • neuron cell-cell adhesion • synaptic vesicle endocytosis • modulation of chemical synaptic transmission • postsynaptic membrane assembly • presynaptic membrane assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1056	n/a
Ensembl	ENSG00000170835	n/a
UniProt	P19835	n/a
RefSeq (mRNA)	NM_001807	n/a
RefSeq (protein)	NP_001798	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CEL yw CEL a elwir hefyd yn Carboxyl ester lipase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CEL.

• BAL
• FAP
• BSDL
• BSSL
• CELL
• FAPP
• LIPA
• CEase
• MODY8

Llyfryddiaeth

• "Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. ". PLoS One. 2016. PMID 27802312.
• "Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. ". Pancreatology. 2017. PMID 27773618.
• "A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. ". J Biol Chem. 2016. PMID 27650499.
• "Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers. ". Oncotarget. 2015. PMID 26498142.
• "Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.". J Biol Chem. 2014. PMID 25160620.