CDKN2A

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CDKN2A
Protein CDKN2A PDB 1a5e.png
Strwythurau
PDBOrthologau:PDBe RCSB
Dynodwyr
CyfenwauCDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A
Dynodwyr allanolOMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A
Patrwm RNA pattern
PBB GE CDKN2A 207039 at.png

PBB GE CDKN2A 209644 x at.png

PBB GE CDKN2A 211156 at.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040654
NM_009877

RefSeq (protein)

NP_001035744
NP_034007
NP_034007.1

Lleoliad (UCSC)n/aChr : 89.27 – 89.29 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN2A yw CDKN2A a elwir hefyd yn Tumor suppressor ARF (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.3.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN2A.

  • ARF
  • MLM
  • P14
  • P16
  • P19
  • CMM2
  • INK4
  • MTS1
  • TP16
  • CDK4I
  • CDKN2
  • INK4A
  • MTS-1
  • P14ARF
  • P19ARF
  • P16INK4
  • P16INK4A
  • P16-INK4A

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. ". Am J Surg Pathol. 2018. PMID 29112019.
  • "Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families. ". J Invest Dermatol. 2017. PMID 28830827.
  • "Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status. ". J Am Acad Dermatol. 2017. PMID 28818438.
  • "Using p16 immunohistochemistry to classify morphologic cervical intraepithelial neoplasia 2: correlation of ambiguous staining patterns with HPV subtypes and clinical outcome. ". Hum Pathol. 2017. PMID 28705710.
  • "Obesity and Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.". Mol Cell Biol. 2017. PMID 28630279.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. 1.0 1.1 1.2 GRCm38: Ensembl release 89: ENSMUSG00000044303 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. CDKN2A - Cronfa NCBI