CDK9

CDK9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
Dynodwyr
Cyfenwau	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK, cyclin-dependent kinase 9, cyclin dependent kinase 9
Dynodwyr allanol	OMIM: 603251 HomoloGene: 55566 GeneCards: CDK9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • transferase activity • protein kinase activity • 7SK snRNA binding • transcription coactivator binding • snRNA binding • ATP binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • protein serine/threonine kinase activity • chromatin binding • kinase activity • cyclin-dependent protein serine/threonine kinase activity • RNA polymerase II CTD heptapeptide repeat kinase activity • protein kinase binding • cyclin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • bilen • nucleoplasm • transcription elongation factor complex • cyclin/CDK positive transcription elongation factor complex • PML body • Cromosom • cytoplasmic ribonucleoprotein granule • cyclin-dependent protein kinase holoenzyme complex Prosesau biolegol • positive regulation of cardiac muscle hypertrophy • positive regulation of mRNA 3'-UTR binding • regulation of muscle cell differentiation • negative regulation of mRNA polyadenylation • GO:0100026 DNA repair • cellular response to cytokine stimulus • positive regulation of viral transcription • replication fork processing • protein phosphorylation • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification • regulation of mitotic cell cycle • cellular response to DNA damage stimulus • transcription initiation from RNA polymerase II promoter • regulation of DNA repair • GO:0009373 regulation of transcription, DNA-templated • cell population proliferation • transcription by RNA polymerase II • phosphorylation • positive regulation of histone H2B ubiquitination • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • snRNA transcription by RNA polymerase II • transcription elongation from RNA polymerase II promoter • phosphorylation of RNA polymerase II C-terminal domain • positive regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1025	n/a
Ensembl	ENSG00000136807	n/a
UniProt	P50750	n/a
RefSeq (mRNA)	NM_001261	n/a
RefSeq (protein)	NP_001252 NP_001252.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK9 yw CDK9 a elwir hefyd yn Cyclin-dependent kinase 9 (CDC2-related kinase), isoform CRA_a a Cyclin dependent kinase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK9.

• TAK
• C-2k
• CTK1
• CDC2L4
• PITALRE

Llyfryddiaeth

• "Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation. ". Epigenetics Chromatin. 2017. PMID 28539972.
• "Cell Cycle-Dependent Kinase Cdk9 Is a Postexposure Drug Target against Human Adenoviruses. ". ACS Infect Dis. 2017. PMID 28434229.
• "Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition. ". J Biol Chem. 2016. PMID 27799305.
• "The point of no return: The poly(A)-associated elongation checkpoint. ". RNA Biol. 2016. PMID 26853452.
• "Overview of CDK9 as a target in cancer research.". Cell Cycle. 2016. PMID 26766294.