CDK7

CDK7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UA2
Dynodwyr
Cyfenwau	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
Dynodwyr allanol	OMIM: 601955 HomoloGene: 1363 GeneCards: CDK7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • ATP-dependent activity, acting on DNA • GO:0001105 transcription coactivator activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • androgen receptor binding • RNA polymerase II CTD heptapeptide repeat kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase activity Cydrannau o'r gell • nucleoplasm • perinuclear region of cytoplasm • cnewyllyn cell • cytoplasm • cyclin-dependent protein kinase activating kinase holoenzyme complex • transcription factor TFIIH holo complex • transcription factor TFIIK complex Prosesau biolegol • termination of RNA polymerase I transcription • androgen receptor signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0009373 regulation of transcription, DNA-templated • phosphorylation • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription by RNA polymerase II • transcription, DNA-templated • cellular response to DNA damage stimulus • Cellraniad • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • cell cycle • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • snRNA transcription by RNA polymerase II • nucleotide-excision repair, preincision complex assembly • GO:0100026 DNA repair • protein stabilization • G1/S transition of mitotic cell cycle • G2/M transition of mitotic cell cycle • GO:0001183 transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1022	n/a
Ensembl	ENSG00000134058 ENSG00000277273	n/a
UniProt	P50613	n/a
RefSeq (mRNA)	NM_001799 NM_001324069 NM_001324070 NM_001324071 NM_001324072 NM_001324074 NM_001324075 NM_001324077 NM_001324078	n/a
RefSeq (protein)	NP_001310998 NP_001310999 NP_001311000 NP_001311001 NP_001311003 NP_001311004 NP_001311006 NP_001311007 NP_001790	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK7 yw CDK7 a elwir hefyd yn Cyclin dependent kinase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK7.

• CAK
• CAK1
• HCAK
• MO15
• STK1
• CDKN7
• p39MO15

Llyfryddiaeth

• "Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. ". Exp Mol Pathol. 2016. PMID 27155449.
• "CDK7-dependent transcriptional addiction in triple-negative breast cancer. ". Cell. 2015. PMID 26406377.
• "THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. ". Mol Cell. 2015. PMID 26257281.
• "Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. ". Mol Cell Biol. 2014. PMID 25047832.
• "Human and Xenopus mo15 messenger-RNA are highly conserved but show different patterns of expression in adult tissues.". Oncol Rep. 1994. PMID 21607529.