CDK6

CDK6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BI7, 1BI8, 1BLX, 1G3N, 1JOW, 1XO2, 2EUF, 2F2C, 3NUP, 3NUX, 4AUA, 4EZ5, 4TTH
Dynodwyr
Cyfenwau	CDK6, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6
Dynodwyr allanol	OMIM: 603368 HomoloGene: 963 GeneCards: CDK6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • cyclin-dependent protein serine/threonine kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • cyclin binding • FBXO family protein binding Cydrannau o'r gell • cytoplasm • centrosome • cell projection • cyclin-dependent protein kinase holoenzyme complex • ruffle • microtubule organizing center • Cytosgerbwd • cnewyllyn cell • cytosol • nucleoplasm • cyclin D2-CDK6 complex Prosesau biolegol • cell differentiation • lateral ventricle development • phosphorylation • positive regulation of cell-matrix adhesion • positive regulation of fibroblast proliferation • dentate gyrus development • regulation of erythrocyte differentiation • astrocyte development • negative regulation of cell differentiation • response to virus • negative regulation of cell cycle • negative regulation of osteoblast differentiation • generation of neurons • Cellraniad • regulation of cell motility • protein phosphorylation • negative regulation of epithelial cell proliferation • regulation of gene expression • cell cycle • type B pancreatic cell development • negative regulation of myeloid cell differentiation • negative regulation of cellular senescence • gliogenesis • negative regulation of cell population proliferation • negative regulation of monocyte differentiation • GO:0072468 signal transduction • regulation of G2/M transition of mitotic cell cycle • regulation of cell population proliferation • cell dedifferentiation • G1/S transition of mitotic cell cycle • GO:1901227 negative regulation of transcription by RNA polymerase II • hematopoietic progenitor cell differentiation • Notch signaling pathway • GO:1901313 positive regulation of gene expression • hemopoiesis • T cell differentiation in thymus • hematopoietic stem cell differentiation • regulation of hematopoietic stem cell differentiation • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1021	n/a
Ensembl	ENSG00000105810	n/a
UniProt	Q00534	n/a
RefSeq (mRNA)	NM_001145306 NM_001259	n/a
RefSeq (protein)	NP_001138778 NP_001250	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK6 yw CDK6 a elwir hefyd yn Cyclin dependent kinase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK6.

• MCPH12
• PLSTIRE

Llyfryddiaeth

• "Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein. ". Protein Sci. 2017. PMID 28168755.
• "CDK6 levels regulate quiescence exit in human hematopoietic stem cells. ". Cell Stem Cell. 2015. PMID 25704240.
• "LINE-1 methylation level and patient prognosis in a database of 208 hepatocellular carcinomas. ". Ann Surg Oncol. 2015. PMID 25319577.
• "Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. ". Blood. 2014. PMID 24764564.
• "MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL.". Cell Cycle. 2014. PMID 24736461.