CDK5

CDK5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8
Dynodwyr
Cyfenwau	CDK5, Cdk5, AW048668, Crk6, LIS7, PSSALRE, cyclin-dependent kinase 5, cyclin dependent kinase 5
Dynodwyr allanol	OMIM: 123831 HomoloGene: 3623 GeneCards: CDK5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• acetylcholine receptor activator activity; • kinase activity; • cytoskeletal protein binding; • ATP binding; • protein kinase activity; • protein serine/threonine kinase activity; • ErbB-3 class receptor binding; • transferase activity; • ephrin receptor binding; • tau-protein kinase activity; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • nucleotide binding; • p53 binding; • ErbB-2 class receptor binding; • cyclin-dependent protein serine/threonine kinase activity; • microtubule binding; • tau protein binding; • Hsp90 protein binding; • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;
Cydrannau o'r gell	• postsynaptic membrane; • bilen; • synapse; • Cytosgerbwd; • cell projection; • lamellipodium; • perikaryon; • filopodium; • growth cone; • neuromuscular junction; • Cellbilen; • axon; • neuronal cell body; • GO:0097483, GO:0097481 postsynaptic density; • cell junction; • dendrite; • protein kinase 5 complex; • presynapse; • nucleoplasm; • cnewyllyn cell; • cytoplasm; • cytosol; • microtubule; • neuron projection; • Schaffer collateral - CA1 synapse; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• synaptic transmission, glutamatergic; • proses rythmig; • negative regulation of cell cycle; • oligodendrocyte differentiation; • synaptic transmission, dopaminergic; • protein phosphorylation; • positive regulation of neuron apoptotic process; • central nervous system neuron development; • regulation of synaptic vesicle recycling; • cell cycle; • regulated exocytosis; • corpus callosum development; • cell population proliferation; • intracellular protein transport; • neuron projection development; • regulation of dendritic spine morphogenesis; • negative regulation of synaptic plasticity; • cerebellar cortex formation; • exocytosis; • adwaith i gocên; • GO:0097285 apoptotic process; • regulation of apoptotic process; • negative regulation of proteolysis; • behavioral response to cocaine; • synaptic vesicle exocytosis; • receptor clustering; • positive regulation of calcium ion-dependent exocytosis; • telencephalon development; • synaptic vesicle endocytosis; • response to wounding; • regulation of postsynaptic membrane potential; • excitatory postsynaptic potential; • synapse assembly; • protein autophosphorylation; • positive regulation of actin cytoskeleton reorganization; • negative regulation of neuron death; • chemical synaptic transmission; • neuron apoptotic process; • neuron projection morphogenesis; • associative learning; • dendrite morphogenesis; • phosphorylation; • calcium ion import; • Schwann cell development; • neuron migration; • cerebellum development; • nervous system development; • regulation of synaptic plasticity; • neuron differentiation; • cerebral cortex development; • axon extension; • sensory perception of pain; • positive regulation of protein binding; • cell-matrix adhesion; • peptidyl-threonine phosphorylation; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of axon extension; • GO:0033109 cortical actin cytoskeleton organization; • protein localization to synapse; • positive regulation of protein targeting to membrane; • positive regulation of protein kinase activity; • visual learning; • regulation of cell migration; • axonogenesis; • positive regulation of neuron death; • receptor catabolic process; • Cellraniad; • negative regulation of protein ubiquitination; • positive regulation of signaling receptor activity; • negative regulation of protein export from nucleus; • layer formation in cerebral cortex; • GO:0035404 peptidyl-serine phosphorylation; • nucleocytoplasmic transport; • cerebellar cortex development; • forebrain development; • motor neuron axon guidance; • cell migration; • skeletal muscle tissue development; • hippocampus development; • regulation of macroautophagy; • regulation of signal transduction by p53 class mediator; • serine phosphorylation of STAT protein; • microtubule cytoskeleton organization; • positive regulation of protein phosphorylation; • mitochondrion organization; • positive regulation of glial cell apoptotic process; • synaptic vesicle transport; • regulation of synaptic transmission, glutamatergic; • synapse pruning; • positive regulation of presynaptic cytosolic calcium concentration; • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration; • regulation of protein localization to plasma membrane; • cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologau
	1020
	n/a
	ENSG00000164885
	n/a
	Q00535
	n/a
	NM_001164410; NM_004935
	n/a
	NP_001157882; NP_004926
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK5 yw CDK5 a elwir hefyd yn Cyclin dependent kinase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK5.

LIS7
PSSALRE

Llyfryddiaeth[golygu | golygu cod]

"Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China. ". Eur J Med Res. 2016. PMID 27406233.
"The O-GlcNAc Modification of CDK5 Involved in Neuronal Apoptosis Following In Vitro Intracerebral Hemorrhage. ". Cell Mol Neurobiol. 2017. PMID 27316643.
"Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway. ". Biochem Biophys Res Commun. 2017. PMID 28842255.
"Inhibition of Cdk5 induces cell death of tumor-initiating cells. ". Br J Cancer. 2017. PMID 28222068.
"Biological functions of CDK5 and potential CDK5 targeted clinical treatments.". Oncotarget. 2017. PMID 28077789.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CDK5 - Cronfa NCBI

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[2]