CDC37

CDC37
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1US7, 2K5B, 2W0G, 2N5X, 2NCA, 5FWM, 5FWL, 5FWK
Dynodwyr
Cyfenwau	CDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone
Dynodwyr allanol	OMIM: 605065 HomoloGene: 38268 GeneCards: CDC37
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • unfolded protein binding • Hsp90 protein binding • kinase binding • chaperone binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • heat shock protein binding • protein kinase regulator activity • protein tyrosine kinase activity • scaffold protein binding Cydrannau o'r gell • extracellular exosome • HSP90-CDC37 chaperone complex • cytoplasm • cytosol • chaperone complex Prosesau biolegol • posttranscriptional regulation of gene expression • protein targeting • protein stabilization • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • positive regulation of mitophagy in response to mitochondrial depolarization • regulation of protein kinase activity • protein folding • peptidyl-tyrosine phosphorylation • ERBB2 signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11140	n/a
Ensembl	ENSG00000105401	n/a
UniProt	Q16543	n/a
RefSeq (mRNA)	NM_007065	n/a
RefSeq (protein)	NP_008996	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDC37 yw CDC37 a elwir hefyd yn Cell division cycle 37 a Hsp90 co-chaperone Cdc37 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDC37.

• P50CDC37

Llyfryddiaeth

• "The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy. ". J Biol Chem. 2009. PMID 19073599.
• "Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. ". Oncogene. 2009. PMID 18931700.
• "How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches. ". Trends Biochem Sci. 2017. PMID 28784328.
• "Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains. ". Biochemistry. 2015. PMID 25619116.
• "Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.". Liver Int. 2015. PMID 25098386.