CD8A

CD8A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AKJ, 1CD8, 1Q69, 2HP4, 3QZW
Dynodwyr
Cyfenwau	CD8A, CD8, Leu2, MAL, p32, CD8a molecule
Dynodwyr allanol	OMIM: 186910 HomoloGene: 133777 GeneCards: CD8A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • coreceptor activity • GO:0001948, GO:0016582 protein binding • MHC class I protein binding • protein kinase binding • MHC class I protein complex binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • T cell receptor complex • extracellular region • plasma membrane raft • external side of plasma membrane Prosesau biolegol • antigen processing and presentation • adaptive immune response • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of immune response • T cell activation • T cell mediated immunity • cell surface receptor signaling pathway • cytotoxic T cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	925	n/a
Ensembl	ENSG00000153563	n/a
UniProt	P01732	n/a
RefSeq (mRNA)	NM_001145873 NM_001768 NM_171827	n/a
RefSeq (protein)	NP_001139345 NP_001759 NP_741969 NP_001369627	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD8A yw CD8A a elwir hefyd yn CD8a molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD8A.

• CD8
• MAL
• p32
• Leu2

Llyfryddiaeth

• "Recurrent Respiratory Infections Revealing CD8α Deficiency. ". J Clin Immunol. 2015. PMID 26563160.
• "Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing. ". Blood. 2015. PMID 26185130.
• "Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients' plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?". Blood Transfus. 2014. PMID 23356971.
• "An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection. ". J Virol. 2012. PMID 22811543.
• "Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia.". Cytometry B Clin Cytom. 2012. PMID 22143984.