CD86

CD86
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1I85, 1NCN
Dynodwyr
Cyfenwau	CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
Dynodwyr allanol	OMIM: 601020 HomoloGene: 10443 GeneCards: CD86
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • coreceptor activity • virus receptor activity • GO:0001948, GO:0016582 protein binding • signaling receptor binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • signaling receptor activity Cydrannau o'r gell • integral component of membrane • intracellular membrane-bounded organelle • bilen • Cellbilen • cell surface • extracellular exosome • external side of plasma membrane Prosesau biolegol • response to yeast • adaptive immune response • response to interferon-gamma • immune system process • cell-cell signaling • T cell costimulation • GO:0010260 heneiddio • myeloid dendritic cell differentiation • cellular response to cytokine stimulus • T cell proliferation involved in immune response • toll-like receptor signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • B cell activation • response to lipopolysaccharide • cellular response to metal ion • negative regulation of T cell anergy • defense response to virus • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of T cell proliferation • positive regulation of cell population proliferation • positive regulation of T-helper 2 cell differentiation • viral entry into host cell • GO:0022415 viral process • toll-like receptor 3 signaling pathway • cellular response to lipopolysaccharide • T cell activation • positive regulation of activated T cell proliferation • phosphatidylinositol phosphate biosynthetic process • positive regulation of protein kinase B signaling • GO:0072468 signal transduction • cell surface receptor signaling pathway • cytokine-mediated signaling pathway • negative regulation of T cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	942	n/a
Ensembl	ENSG00000114013	n/a
UniProt	P42081	n/a
RefSeq (mRNA)	NM_176892 NM_001206924 NM_001206925 NM_006889 NM_175862	n/a
RefSeq (protein)	NP_001193853 NP_001193854 NP_008820 NP_787058 NP_795711	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD86 yw CD86 a elwir hefyd yn CD86 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD86.

• B70
• B7-2
• B7.2
• LAB72
• CD28LG2

Llyfryddiaeth

• "Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML. ". Leukemia. 2017. PMID 28074067.
• "Increased CD86 but Not CD80 and PD-L1 Expression on Liver CD68+ Cells during Chronic HBV Infection. ". PLoS One. 2016. PMID 27348308.
• "Functional polymorphisms in CD86 gene are associated with susceptibility to pneumonia-induced sepsis. ". APMIS. 2015. PMID 25912130.
• "Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis. ". PLoS One. 2014. PMID 25369324.
• "CD86 polymorphism affects pneumonia-induced sepsis by decreasing gene expression in monocytes.". Inflammation. 2015. PMID 25129060.