CD81

CD81
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1G8Q, 1IV5, 3X0E, 5DFW, 5DFV
Dynodwyr
Cyfenwau	CD81, CVID6, S5.7, TAPA1, TSPAN28, CD81 molecule
Dynodwyr allanol	OMIM: 186845 HomoloGene: 20915 GeneCards: CD81
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • MHC class II protein complex binding • transferrin receptor binding • virus receptor activity • integrin binding • cholesterol binding • lipid binding Cydrannau o'r gell • integral component of membrane • fesigl • bilen • focal adhesion • integral component of plasma membrane • immunological synapse • extracellular exosome • Cellbilen • basolateral plasma membrane Prosesau biolegol • positive regulation of 1-phosphatidylinositol 4-kinase activity • GO:0034613 protein localization • regulation of protein stability • receptor internalization • cellular response to low-density lipoprotein particle stimulus • regulation of cell motility • receptor-mediated virion attachment to host cell • protein localization to lysosome • cell surface receptor signaling pathway • positive regulation of B cell proliferation • positive regulation of cell population proliferation • regulation of immune response • positive regulation of peptidyl-tyrosine phosphorylation • viral entry into host cell • positive regulation of protein catabolic process in the vacuole • cell population proliferation • GO:0022415 viral process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of complement activation • humoral immune response mediated by circulating immunoglobulin • protein localization to plasma membrane • adaptive immune response • immune system process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	975	n/a
Ensembl	ENSG00000110651	n/a
UniProt	P60033	n/a
RefSeq (mRNA)	NM_001297649 NM_004356	n/a
RefSeq (protein)	NP_001284578 NP_004347	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD81 yw CD81 a elwir hefyd yn CD81 antigen a CD81 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD81.

• S5.7
• CVID6
• TAPA1
• TSPAN28

Llyfryddiaeth

• "A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. ". PLoS One. 2017. PMID 28481946.
• "CD81 as a tumor target. ". Biochem Soc Trans. 2017. PMID 28408492.
• "Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop. ". Structure. 2017. PMID 27916518.
• "Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. ". Cell. 2016. PMID 27881302.
• "Oligomerization of the Tetraspanin CD81 via the Flexibility of Its δ-Loop.". Biophys J. 2016. PMID 27276264.