CD59

CD59
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
Dynodwyr
Cyfenwau	CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule, CD59 molecule (CD59 blood group)
Dynodwyr allanol	OMIM: 107271 HomoloGene: 56386 GeneCards: CD59
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • complement binding Cydrannau o'r gell • fesigl • endoplasmic reticulum membrane • bilen • focal adhesion • Golgi membrane • Cellbilen • extracellular region • cell surface • compact myelin • anchored component of external side of plasma membrane • ER to Golgi transport vesicle membrane • anchored component of membrane • sarcolemma • extracellular exosome • endoplasmic reticulum-Golgi intermediate compartment membrane • extracellular space • specific granule membrane • tertiary granule membrane • transport vesicle Prosesau biolegol • blood coagulation • negative regulation of apoptotic process • negative regulation of activation of membrane attack complex • endoplasmic reticulum to Golgi vesicle-mediated transport • cell surface receptor signaling pathway • COPII vesicle coating • positive regulation of T cell proliferation • regulation of complement activation • cell activation • neutrophil degranulation • regulation of complement-dependent cytotoxicity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	966	n/a
Ensembl	ENSG00000085063	n/a
UniProt	P13987 Q6FHM9	n/a
RefSeq (mRNA)	NM_203331 NM_000611 NM_001127223 NM_001127225 NM_001127226 NM_001127227 NM_203329 NM_203330	n/a
RefSeq (protein)	NP_000602 NP_001120695 NP_001120697 NP_001120698 NP_001120699 NP_976074 NP_976075 NP_976076 NP_000602.1 NP_001120695.1 NP_001120697.1 NP_001120698.1 NP_001120699.1 NP_976074.1 NP_976075.1 NP_976076.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD59 yw CD59 a elwir hefyd yn CD59 antigen, complement regulatory protein, isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD59.

• 1F5
• EJ16
• EJ30
• EL32
• G344
• MIN1
• MIN2
• MIN3
• MIRL
• HRF20
• MACIF
• MEM43
• MIC11
• MSK21
• 16.3A5
• HRF-20
• MAC-IP
• p18-20

Llyfryddiaeth

• "A distinctive histidine residue is essential for in vivo glycation-inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications. ". Am J Hematol. 2017. PMID 28815695.
• "Demyelination, strokes, and eculizumab: Lessons from the congenital CD59 gene mutations. ". Mol Immunol. 2017. PMID 28622911.
• "Therapy with eculizumab for patients with CD59 p.Cys89Tyr mutation. ". Ann Neurol. 2016. PMID 27568864.
• "Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. ". Structure. 2016. PMID 27499440.
• "CD59: A long-known complement inhibitor has advanced to a blood group system.". Immunohematology. 2015. PMID 27187193.