CD59

CD59
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
Dynodwyr
Cyfenwau	CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule, CD59 molecule (CD59 blood group)
Dynodwyr allanol	OMIM: 107271 HomoloGene: 56386 GeneCards: CD59
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • complement binding;
Cydrannau o'r gell	• fesigl; • endoplasmic reticulum membrane; • bilen; • focal adhesion; • Golgi membrane; • Cellbilen; • extracellular region; • cell surface; • compact myelin; • anchored component of external side of plasma membrane; • ER to Golgi transport vesicle membrane; • anchored component of membrane; • sarcolemma; • extracellular exosome; • endoplasmic reticulum-Golgi intermediate compartment membrane; • extracellular space; • specific granule membrane; • tertiary granule membrane; • transport vesicle;
Prosesau biolegol	• blood coagulation; • negative regulation of apoptotic process; • negative regulation of activation of membrane attack complex; • endoplasmic reticulum to Golgi vesicle-mediated transport; • cell surface receptor signaling pathway; • COPII vesicle coating; • positive regulation of T cell proliferation; • regulation of complement activation; • cell activation; • neutrophil degranulation; • regulation of complement-dependent cytotoxicity;
	Sources:Amigo / QuickGO
Orthologau
	966
	n/a
	ENSG00000085063
	n/a
	P13987; Q6FHM9
	n/a
NM_203331; NM_000611; NM_001127223; NM_001127225; NM_001127226;
	NM_001127227; NM_203329; NM_203330
	n/a
NP_000602; NP_001120695; NP_001120697; NP_001120698; NP_001120699;
	NP_976074; NP_976075; NP_976076; NP_000602.1; NP_001120695.1; NP_001120697.1; NP_001120698.1; NP_001120699.1; NP_976074.1; NP_976075.1; NP_976076.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD59 yw CD59 a elwir hefyd yn CD59 antigen, complement regulatory protein, isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD59.

1F5
EJ16
EJ30
EL32
G344
MIN1
MIN2
MIN3
MIRL
HRF20
MACIF
MEM43
MIC11
MSK21
16.3A5
HRF-20
MAC-IP
p18-20

Llyfryddiaeth

"A distinctive histidine residue is essential for in vivo glycation-inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications. ". Am J Hematol. 2017. PMID 28815695.
"Demyelination, strokes, and eculizumab: Lessons from the congenital CD59 gene mutations. ". Mol Immunol. 2017. PMID 28622911.
"Therapy with eculizumab for patients with CD59 p.Cys89Tyr mutation. ". Ann Neurol. 2016. PMID 27568864.
"Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. ". Structure. 2016. PMID 27499440.
"CD59: A long-known complement inhibitor has advanced to a blood group system.". Immunohematology. 2015. PMID 27187193.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CD59 - Cronfa NCBI

[1]

[2]