CD46

CD46
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Dynodwyr
Cyfenwau	CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
Dynodwyr allanol	OMIM: 120920 HomoloGene: 7832 GeneCards: CD46
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • virus receptor activity • cadherin binding • GO:0001948, GO:0016582 protein binding • complement binding • endopeptidase activity • GO:0048551 enzyme inhibitor activity • signaling receptor activity Cydrannau o'r gell • integral component of membrane • inner acrosomal membrane • bilen • focal adhesion • Cellbilen • integral component of plasma membrane • cell surface • extracellular exosome • GO:0016023 cytoplasmic vesicle • acrosomal vesicle • cytoplasm • Golgi apparatus • basolateral plasma membrane Prosesau biolegol • T cell mediated immunity • adaptive immune response • positive regulation of interleukin-10 production • immune system process • sequestering of extracellular ligand from receptor • positive regulation of regulatory T cell differentiation • negative regulation of gene expression • single fertilization • GO:1901313 positive regulation of gene expression • positive regulation of T cell proliferation • positive regulation of memory T cell differentiation • complement activation, classical pathway • positive regulation of transforming growth factor beta production • viral entry into host cell • GO:0022415 viral process • regulation of Notch signaling pathway • regulation of complement activation • interleukin-10 production • innate immune response • proteolysis • GO:0048553 negative regulation of catalytic activity • negative regulation of complement activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4179	n/a
Ensembl	ENSG00000117335	n/a
UniProt	P15529	n/a
RefSeq (mRNA)	NM_002389 NM_153826 NM_172350 NM_172351 NM_172352 NM_172353 NM_172354 NM_172355 NM_172356 NM_172357 NM_172358 NM_172359 NM_172360 NM_172361	n/a
RefSeq (protein)	NP_002380 NP_722548 NP_758860 NP_758861 NP_758862 NP_758863 NP_758869 NP_758871 NP_758865 NP_758866 NP_758867 NP_758868	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD46 yw CD46 a elwir hefyd yn Membrane cofactor protein a CD46 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD46.

• MCP
• TLX
• AHUS2
• MIC10
• TRA2.10

Llyfryddiaeth

• "Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus. ". Eur J Immunol. 2017. PMID 28444759.
• "Divergent tropism of HHV-6AGS and HHV-6BPL1 in T cells expressing different CD46 isoform patterns. ". Virology. 2017. PMID 28056415.
• "Association of CD46 IVS1-1724 C>G Single Nucleotide Polymorphism in Iranian Women with Unexplained Recurrent Spontaneous Abortion (URSA). ". Iran J Allergy Asthma Immunol. 2016. PMID 27921411.
• "Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. ". J Clin Invest. 2016. PMID 27841764.
• "CD46 accelerates macrophage-mediated host susceptibility to meningococcal sepsis in a murine model.". Eur J Immunol. 2017. PMID 27794168.