CD3E

CD3E
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A81, 1SY6, 1XIW, 2ROL
Dynodwyr
Cyfenwau	CD3E, IMD18, T3E, TCRE, CD3e molecule, CD3epsilon, CD3 epsilon subunit of T-cell receptor complex
Dynodwyr allanol	OMIM: 186830 HomoloGene: 586 GeneCards: CD3E
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • signaling receptor complex adaptor activity • T cell receptor binding • protein kinase binding • transmembrane signaling receptor activity • protein homodimerization activity Cydrannau o'r gell • integral component of membrane • bilen • cell-cell junction • alpha-beta T cell receptor complex • Cellbilen • integral component of plasma membrane • T cell receptor complex • immunological synapse • external side of plasma membrane • dendritic spine • cell body Prosesau biolegol • regulation of apoptotic process • G protein-coupled receptor signaling pathway • positive regulation of calcium-mediated signaling • negative regulation of smoothened signaling pathway • T cell differentiation in thymus • response to nutrient • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • T cell costimulation • positive regulation of interferon-gamma production • signal complex assembly • negative regulation of gene expression • positive regulation of interleukin-4 production • negative thymic T cell selection • cell surface receptor signaling pathway • GO:1901313 positive regulation of gene expression • positive regulation of T cell anergy • positive regulation of T cell activation • positive regulation of T cell proliferation • positive regulation of alpha-beta T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • regulation of immune response • apoptotic signaling pathway • lymphocyte activation • T cell receptor signaling pathway • T cell activation • protein homooligomerization • dendrite development • cerebellum development • adaptive immune response • GO:0034622 protein-containing complex assembly • positive regulation of cell-matrix adhesion • T cell differentiation • positive regulation of cell-cell adhesion mediated by integrin • positive thymic T cell selection Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	916	n/a
Ensembl	ENSG00000198851	n/a
UniProt	P07766	n/a
RefSeq (mRNA)	NM_000733	n/a
RefSeq (protein)	NP_000724	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD3E yw CD3E a elwir hefyd yn CD3e molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD3E.

• T3E
• TCRE
• IMD18

Llyfryddiaeth

• "A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey. ". Immunogenetics. 2017. PMID 28597365.
• "Change in CD3ζ-chain expression is an independent predictor of disease status in head and neck cancer patients. ". Int J Cancer. 2016. PMID 26888626.
• "Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. ". J Exp Med. 2012. PMID 23166358.
• "Lung carcinomas do not induce T-cell apoptosis via the Fas/Fas ligand pathway but down-regulate CD3 epsilon expression. ". Cancer Immunol Immunother. 2008. PMID 17668204.
• "Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.". Blood. 2007. PMID 17630354.