CCS

CCS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DO5, 2CRL, 2RSQ
Dynodwyr
Cyfenwau	CCS, copper chaperone for superoxide dismutase
Dynodwyr allanol	OMIM: 603864 HomoloGene: 3762 GeneCards: CCS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-disulfide reductase activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • copper ion binding • cadherin binding • superoxide dismutase copper chaperone activity • superoxide dismutase activity Cydrannau o'r gell • cytosol • cnewyllyn cell • cytoplasm • extracellular space Prosesau biolegol • GO:1900490 positive regulation of oxidoreductase activity • protein maturation by copper ion transfer • GO:0070839 metal ion transport • superoxide metabolic process • cellular response to oxidative stress • removal of superoxide radicals Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9973	n/a
Ensembl	ENSG00000173992	n/a
UniProt	O14618	n/a
RefSeq (mRNA)	NM_005125	n/a
RefSeq (protein)	NP_005116	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCS yw CCS a elwir hefyd yn Copper chaperone for superoxide dismutase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.

Llyfryddiaeth

• "Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase. ". Hum Mutat. 2012. PMID 22508683.
• "The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies. ". Biochem J. 2011. PMID 21722094.
• "CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes. ". Biometals. 2014. PMID 24855044.
• "Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria. ". Nat Commun. 2013. PMID 24026195.
• "Copper chaperone for superoxide dismutase-1 transfers copper to mitochondria but does not affect cytochrome c oxidase activity.". Exp Biol Med (Maywood). 2013. PMID 23900152.