CCNK

CCNK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I53, 4CXA, 4NST, 4UN0, 5EFQ, 5ACB
Dynodwyr
Cyfenwau	CCNK, CPR4, Cyclin K, IDDHDF
Dynodwyr allanol	OMIM: 603544 HomoloGene: 14748 GeneCards: CCNK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein kinase binding • RNA polymerase II CTD heptapeptide repeat kinase activity • cyclin-dependent protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • protein serine/threonine kinase activity • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity Cydrannau o'r gell • cyclin K-CDK12 complex • cnewyllyn cell • cyclin K-CDK13 complex • nucleoplasm • cyclin-dependent protein kinase holoenzyme complex • cyclin/CDK positive transcription elongation factor complex Prosesau biolegol • positive regulation of cyclin-dependent protein serine/threonine kinase activity • transcription elongation from RNA polymerase II promoter • regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues • GO:0009373 regulation of transcription, DNA-templated • cellular response to DNA damage stimulus • transcription by RNA polymerase II • negative regulation by host of viral genome replication • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Cellraniad • cell cycle • protein phosphorylation • transcription, DNA-templated • snRNA transcription by RNA polymerase II • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of DNA-templated transcription, elongation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8812	n/a
Ensembl	ENSG00000090061	n/a
UniProt	O75909	n/a
RefSeq (mRNA)	NM_001099402 NM_003858	n/a
RefSeq (protein)	NP_001092872	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCNK yw CCNK a elwir hefyd yn Cyclin-K a Cyclin K (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCNK.

• CPR4

Llyfryddiaeth

• "Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. ". Nucleic Acids Res. 2015. PMID 25712099.
• "A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis. ". PLoS One. 2014. PMID 25004108.
• "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. ". J Mol Biol. 2007. PMID 17169370.
• "Structural and Functional Analysis of the Cdk13/Cyclin K Complex. ". Cell Rep. 2016. PMID 26748711.
• "Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.". Sci Rep. 2015. PMID 26597175.