CCNH

CCNH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JKW, 1KXU
Dynodwyr
Cyfenwau	CCNH, CAK, CycH, p34, p37, Cyclin H
Dynodwyr allanol	OMIM: 601953 HomoloGene: 946 GeneCards: CCNH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATP-dependent activity, acting on DNA • kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • GO:0001948, GO:0016582 protein binding • RNA polymerase II CTD heptapeptide repeat kinase activity Cydrannau o'r gell • nucleoplasm • transcription factor TFIIH holo complex • transcription factor TFIIK complex • cnewyllyn cell • cyclin-dependent protein kinase activating kinase holoenzyme complex • cyclin-dependent protein kinase holoenzyme complex Prosesau biolegol • termination of RNA polymerase I transcription • GO:0009373 regulation of transcription, DNA-templated • phosphorylation • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription by RNA polymerase II • transcription, DNA-templated • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • positive regulation of cyclin-dependent protein serine/threonine kinase activity • cell cycle • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein phosphorylation • nucleotide-excision repair, preincision complex assembly • protein stabilization • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • G1/S transition of mitotic cell cycle • G2/M transition of mitotic cell cycle • GO:0001183 transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	902	n/a
Ensembl	ENSG00000134480	n/a
UniProt	P51946	n/a
RefSeq (mRNA)	NM_001199189 NM_001239 NM_001363539 NM_001364075 NM_001364076	n/a
RefSeq (protein)	NP_001186118 NP_001230 NP_001350468 NP_001351004 NP_001351005	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCNH yw CCNH a elwir hefyd yn Cyclin H (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCNH.

• CAK
• p34
• p37
• CycH

Llyfryddiaeth

• "The role of CCNH Val270Ala (rs2230641) and other nucleotide excision repair polymorphisms in individual susceptibility to well-differentiated thyroid cancer. ". Oncol Rep. 2013. PMID 23982724.
• "Cyclin H expression is increased in GIST with very-high risk of malignancy. ". BMC Cancer. 2010. PMID 20598140.
• "Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. ". Hum Pathol. 2008. PMID 18400256.
• "The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies. ". Mol Biol Cell. 1997. PMID 9243502.
• "The structure of cyclin H: common mode of kinase activation and specific features.". EMBO J. 1997. PMID 9118957.